临床与病理杂志2017，Vol.37Issue(7)：1490-1495,6.DOI:10.3978/j.issn.2095-6959.2017.07.029
常染色质组蛋白甲基化转移酶与哺乳动物生殖
Euchromatin histone lysine methyltransferases and early mammalian development
摘要
Abstract
Euchromatin histone lysine methyltransferases (EHMTs) can be known to making histone 39th lysine demethylate (H3K9-di) in the region of chromatin. In mammals, there are two kinds of proteins encoded by EHMT genes,EHMT1 encodes GLP andEHMT2 encodes G9a, respectively. EHMTs plays a different role in differentiation progress of various tissues and cells and also involves in the formation of adult specific reaction processes, such as memory, drug addiction, immunoreaction, etc.EHMTs and theirs proteins play an important role in gametogenesis, embryo development and uterine diseases of mammalian reproductive process.关键词
表观遗传/常染色质组蛋白甲基化转移酶/G9a/生殖发育Key words
epigenetics/euchromatin histone lysine methyltransferases/G9a/reproductive development引用本文复制引用
马妮..常染色质组蛋白甲基化转移酶与哺乳动物生殖[J].临床与病理杂志,2017,37(7):1490-1495,6.基金项目
国家自然科学基金(31671565) （31671565）
湖北省自然科学基金(2015CFB543) （2015CFB543）
湖北医药学院创新团队(2014CXX03, FDFR201604) （2014CXX03, FDFR201604）
湖北医药学院重点学科建设项目.This work was supported by the National Natural Science Foundation (31671565), the Natural Science Foundation of Hubei Province (2015CFB543), Innovation Team of Hubei University of Medicine (2014CXX03, FDFR201604) and Hubei University of Medicine Academic Discipline Project, China. （31671565）
