海南医学院学报2017，Vol.23Issue(13)：1748-1751,4.DOI:10.13210/j.cnki.jhmu.20170809.021
重组人脑利钠肽治疗对急性心肌梗死伴心力衰竭患者血清炎性因子、神经内分泌激素及心功能的影响
Effect of recombinant human brain natriuretic peptide on serum inflammatory factors, neuroendocrine hormones and cardiac function in patients with acute myocardial infarction complicated with heart failure
摘要
Abstract
Objective:To investigate the effect of recombinant human brain natriuretic peptide (BNP) on inflammatory factors,neuroendocrine hormones and cardiac function indexes in patients with acute myocardial infarction complicated with heart failure.Methods:A total of 91 cases of acute myocardial infarction with heart failure patients were divided into the control group (n=44) and observation group (n=47) according to the random data table.Based on conventional treatment,the control group was given intravenous infusion of Nitroglycerin Injection treatment,while the observation group received intravenous injection of recombinant human brain natriuretic peptide treatment.Serum inflammatory factors,neuroendocrine hormone and cardiac function and other indexes of two groups before and after treatment were compared between the two groups.Results:Before treatment,there was no significant difference in detected parameters between the two groups (P>0.05).After treatment,the levels of TNF-α,hs-CRP,IL-6,MCP-1,LVESD and LVEDD in the two groups were significantly lower than that before treatment (P<0.05),and these levels in the observation group were significant lower than that of the control group (P<0.05).After treatment,LVEF levels were significantly higher than those before treatment (P<0.05),and the increase in the observation group was more obvious than that that of control group (P<0.05).After treatment,PRA,Ang II and ALD and NE levels in both groups were significantly lower than those before treatment (P<0.05),and the levels in the observation group was significantly lower than that of the control group (P<0.05).But PRA,Ang,ALD and NE levels of control group showed no significant difference (P>0.05) comparing with that before treatment.Conclusion:Recombinant human brain natriuretic peptide can effectively reduce the serum inflammatory factors and neuroendocrine hormone levels,improve heart function for patients with acute myocardial infarction with heart failure.关键词
急性心肌梗死/心力衰竭/重组人脑利钠肽/炎性因子/神经内分泌激素/心功能Key words
Acute myocardial infarction/Heart failure/Recombinant human brain natriuretic peptide/Inflammatory factor/Neuroendocrine hormone/Cardiac function分类
医药卫生引用本文复制引用
李珊珊,张毅刚,曹秋玫..重组人脑利钠肽治疗对急性心肌梗死伴心力衰竭患者血清炎性因子、神经内分泌激素及心功能的影响[J].海南医学院学报,2017,23(13):1748-1751,4.基金项目
江苏省基础研究计划(自然科学基金)重点项目(BK2015125) （自然科学基金）
This study was supported by Basic Research Priorities Program(Natural Science Fund) of Jiangsu Province (BK2015125). （Natural Science Fund）
