海南医学院学报2017，Vol.23Issue(13)：1755-1758,4.DOI:10.13210/j.cnki.jhmu.20170607.011
培哚普利对心肌梗死后心力衰竭患者心肌能量消耗的影响
Effect of perindopril on myocardial energy consumption in patients with heart failure after myocardial infarction
摘要
Abstract
Objective:To explore the clinical efficacy of perinodopril in the treatment of heart failure in patients after myocardial infarction and effect on the myocardial energy consumption.Methods:A total of 87 patients with heart failure after myocardial infarction who were admitted in our hospital from August,2014 to October,2015 were included in the study and divided into the routine dose group (n=43,perinodopril 4 mg/d) and high dose group (n=44,perinodopril 8 mg/d) according to the long-term oral dose.All the patients were given perinodopril,continuously for 6 months.The changes of blood pressure and serum biochemical indicators before and after treatment in the two groups were compared.The changes of cardiac function indicators and myocardial energy consumption indicators before and after treatment in the two groups were compared.6MWT 6 months and 1 year after treatment in the two groups was calculated.Results:The plasma BNP and H-FABP levels,LVEDD,LVESD,MEE,and cESS after treatment in the two groups were significantly reduced when compared with before treatment,and those in the high dose group were significantly lower than those in the low dose group (P<0.01).LVEF and FS after treatment in the two groups were significantly increased,and those in the high dose group were significantly greater than those in the routine dose group (P<0.01).The seurm potassium level after treatment in the high dose group was significantly elevated when compared with before treatment (P<0.01),but was not significantly different from that in the routine dose group (P>0.05).SBP,DBP,and Scr levels after treatment in the two groups were not significantly changed (P>0.05).6MWT 6 months and 1 year after treatment in the high dose group was significantly greater than that in the routine dose group (P<0.01).Conclusions:Perinodopril in high dose can significantly reduce the plasma BNP and H-FABP levels in patients with heart failure after myocardial infarction,inhibit the ventricular remodeling,promote the recovery of systolic function,reduce the myocardial energy consumption,and will not affect the blood pressure,serum potassium,and renal function,with efficacy significantly superior to that in a low dose;moreover,it has a certain safety.关键词
心肌梗死/心力衰竭/培哚普利/心功能/心肌能量消耗Key words
Myocardial infarction/Heart failure/Perinodopril/Cardiac function/Myocardial energy consumption分类
医药卫生引用本文复制引用
李大鹏,孙党辉,魏林,于熙莹,那世敬..培哚普利对心肌梗死后心力衰竭患者心肌能量消耗的影响[J].海南医学院学报,2017,23(13):1755-1758,4.基金项目
黑龙江省卫生计生委科研项目(2014-003) （2014-003）
It is supported by Health and Family Planning Commission of Heilongjiang Province (2014-003). （2014-003）
