海南医学院学报2017，Vol.23Issue(13)：1759-1761,1765,4.DOI:10.13210/j.cnki.jhmu.20170809.024
叶酸和维生素B12辅助治疗对老年冠心病慢性心力衰竭患者血清炎性因子、Hcy和NT-proBNP的影响
Effect of folic acid and vitamin B12 adjuvant therapy on serum inflammatory cytokines, Hcy and NT-proBNP in elderly patients with coronary heart disease and chronic heart failure
摘要
Abstract
Objective:To investigate the effect of folic acid combined with vitamin B12 supplementation with conventional drugs on the levels of serum inflammatory factors,Hcy and NT-proBNP in elderly patients with chronic heart failure.Methods:A total of 89 elderly patients with chronic heart failure were randomly divided into control group (n=47) and observation group (n=42) based on the random data table.The control group was given diuretics,ACEI and β receptor inhibitor group of three categories of drugs combined treatment,on this basis,the observation group was supplemented by folic acid tablets and vitamin B12 treatment.Both groups treated lasted for 8 weeks.The levels of TNF-α,hs-CRP and visfatin,Hcy and NT-proBNP were measured before and after treatment in both groups.Results:There was no significant difference in TNF-α,hs-CRP,visfatin,Hcy and NT-proBNP between control group and observation group before treatment (P>0.05).After treatment,the levels of TNF-α,hs-CRP,visfatin,Hcy and NT-proBNP in two groups were decreased significantly (P<0.05),the level of the above indexes of the observation group after treatment was significantly lower than that of the control group (P<0.05).Conclusions:Folic acid combined with vitamin B12 can reduce the levels of serum inflammatory factors,Hcy and NT-proBNP in elderly patients with coronary heart disease and heart failure,which has certain clinical value.关键词
冠心病慢性心力衰竭/叶酸/维生素B12Key words
Coronary heart disease chronic heart failure/Folic acid/Vitamin B12分类
医药卫生引用本文复制引用
窦灵芝,张毅刚,曹秋玫,刘子夏..叶酸和维生素B12辅助治疗对老年冠心病慢性心力衰竭患者血清炎性因子、Hcy和NT-proBNP的影响[J].海南医学院学报,2017,23(13):1759-1761,1765,4.基金项目
徐州市科技支撑项目(XZZD1511) （XZZD1511）
This study was supported by Science and Technology Support Project of Xuzhou City (Grant No.XZZD1511) （Grant No.XZZD1511）
