海南医学院学报2017，Vol.23Issue(13)：1773-1775,1779,4.DOI:10.13210/j.cnki.jhmu.20170809.034
叶酸联合常规药物对H型高血压合并颈动脉粥样硬化患者Hcy代谢、炎症反应、斑块性质的影响
Effect of folic acid combined with routine drugs on Hcy metabolism, inflammatory response and plaque properties in patients with H-type hypertension complicated by carotid atherosclerosis
摘要
Abstract
Objective:To explore the effect of folic acid combined with routine drugs on Hcy metabolism,inflammatory response and plaque properties in patients with H-type hypertension complicated by carotid atherosclerosis.Methods:A total of 68 patients with H-type hypertension complicated by carotid atherosclerosis who received treatment in our hospital between January 2014 and September 2016 were collected and divided into control group (n=34) and observation group (n=34) according to random number table.The control group received routine therapy while the observation group received folic acid combined with routine drug therapy.The differences in Hcy metabolism,inflammatory response and plaque properties were compared between the two groups of patients before and after treatment.Results:Before treatment,differences in serum Hcy contents,pro-inflammatory and anti-inflammatory mediator contents,and ultrasound plaque property parameter levels were not statistically significant between two groups of patients (P>0.05).After treatment,serum Hcy content of observation group was significantly lower than that of control group (P<0.05);serum pro-inflammatory factors IL-1,IL-6,IL-8 and CRP contents were significantly lower than those of control group (P<0.05);serum anti-inflammatory factors IL-4,IL-10 and IL-13 contents were significantly lower than those of control group (P<0.05);ultrasound plaque property parameter strain value was significantly lower than that of control group while plaque strain rate was significantly higher than that of control group (P<0.05).Conclusions:Folic acid treatment based on routine treatment can effectively accelerate Hcy metabolism,reduce systemic inflammatory response and increase plaque stability in patients with H-type hypertension complicated by carotid atherosclerosis.关键词
H型高血压/颈动脉粥样硬化/叶酸/同型半胱氨酸/炎症反应Key words
H-type hypertension/Carotid atherosclerosis/Folic acid/Homocysteine/Inflammatory response分类
医药卫生引用本文复制引用
黄强,李美茹..叶酸联合常规药物对H型高血压合并颈动脉粥样硬化患者Hcy代谢、炎症反应、斑块性质的影响[J].海南医学院学报,2017,23(13):1773-1775,1779,4.基金项目
国家十二五重大专项(2012zx09101105) （2012zx09101105）
This study was supported by China's 12th Five Year Plan (Grant No.2012zx09101105) （Grant No.2012zx09101105）
