海南医学院学报2017，Vol.23Issue(13)：1780-1782,1786,4.DOI:10.13210/j.cnki.jhmu.20170628.009
MODS患者肠道菌群紊乱与机体免疫应答、炎症反应的相关性分析
Correlation of intestinal flora disturbance with immune response and inflammatory response in patients with MODS
摘要
Abstract
Objective:To study the correlation of intestinal flora disturbance with immune response and inflammatory response in patients with MODS.Methods:A total of 60 patients with MODS who were treated in our hospital between August 2013 and January 2017 were collected as observation group,and 50 healthy subjects who received physical examination in our hospital during the same period were collected as normal control group.The intestinal flora distribution in the feces samples,peripheral blood contents of T lymphocyte subsets and serum levels of immunoglobulin and inflammatory factors were compared between two groups of subjects.The relationship of intestinal flora distribution with immune response and inflammatory response was assessed by Pearson test.Results:Bifidobacterium and lactobacillus counts as well as B/E value in feces of observation group were lower than those of normal control group while escherichia coli and enterococcus count were higher than those of normal control group;peripheral blood CD4+T lymphocyte proportion and CD4+/CD8+ ratio were significantly lower than those of normal control group while CD8+T lymphocyte proportion was significantly higher than that of normal control group (P<0.05);serum immunoglobulin IgA,IgM and IgG levels were significantly lower than those of normal control group (P<0.05);serum inflammatory factors PCT,IL-1,IL-6,IL-8 and TNF-α levels were significantly higher than those of normal control group (P<0.05).Pearson test showed that the intestinal flora disturbance in patients with MODS is directly correlated with the immune response function and inflammatory response.Conclusions:There is obvious intestinal flora disturbance in patients with MODS,and it is one of the important causes of immune function injury and systemic inflammatory response in patients.关键词
多器官功能障碍综合征/肠道菌群紊乱/免疫应答/炎症反应Key words
Multiple organ dysfunction syndrome/Intestinal flora disturbance/Immune response/Inflammatory response分类
医药卫生引用本文复制引用
张炤杰..MODS患者肠道菌群紊乱与机体免疫应答、炎症反应的相关性分析[J].海南医学院学报,2017,23(13):1780-1782,1786,4.基金项目
江苏省卫生厅预防医学资助项目(Y2013028) （Y2013028）
This study was supported by Preventive Medicine Project of Jiangsu Provincial Health Department (Grant No.Y2013028) （Grant No.Y2013028）
