海南医学院学报2017，Vol.23Issue(13)：1801-1804,4.DOI:10.13210/j.cnki.jhmu.20170628.004
通心络联合曲美他嗪在急性ST段抬高型心肌梗死经皮冠状动脉介入术后应用对心功能的影响
Clinical study on the effect of Tongxinluo combined with trimetazidine on cardiac function in patients with acute ST-segment elevation myocardial infarction after percutaneous coronary intervention
摘要
Abstract
Objective:To investigate the clinical effect of Tongxinluo combined with trimetazidine on cardiac function in patients with acute ST-segment elevation myocardial infarction after percutaneous coronary intervention.Methods:From March 2014 to September 2016,190 patients with ST-segment elevation myocardial infarction with percutaneous coronary intervention were selected.According to the admission time,the patients were divided into observation group and control group.The control group was treated with conventional therapy (aspirin,isosorbide dinitrate,metoprolol tartrate,clopidogrel sulfate,captopril,atorvastatin calcium and diuretics) and trimetazidine,and the observation group based on the control group was given Tongxinluo combined treatment.Each group of 95 cases,hs-CRP,aldosterone,NT-proBNP,TNF-α,IL-6,and cardiac function (LVEDV、LVESV、LVEF、SV) were compared.Results:After treatment,the biochemical indexes of the two groups were significantly lower than those before the treatment (P<0.05).The Hs-CRP,aldosterone,NT-proBNP,TNF-α and IL-6 in the observation group were significantly lower than those in the control group (P<0.05);The cardiac function indexes of the two groups were significantly improved after treatment.LVVEV and LVESV in the observation group were significantly lower than in the control group;LVEF and SV were significantly higher than those in the control group (P<0.05).Conclusions:Tongxinluo combined with trimetazidine in patients with acute ST-segment elevation myocardial infarction after percutaneous coronary intervention in patients with clinical effect is better,can stablize plaque,and effectively improve microcirculation and cardiac function.A wide range of clinical application is recommended.关键词
通心络/曲美他嗪/急性ST段抬高型心肌梗死/经皮冠状动脉介入/心功能Key words
Tongxinluo/Trimetazidine/Acute ST-segment elevation myocardial infarction/Percutaneous coronary intervention/Cardiac function分类
医药卫生引用本文复制引用
范群雄,赵继先,张焕鑫,李波,李峥嵘..通心络联合曲美他嗪在急性ST段抬高型心肌梗死经皮冠状动脉介入术后应用对心功能的影响[J].海南医学院学报,2017,23(13):1801-1804,4.基金项目
湖北省卫生厅计划项目(鄂卫2015-53) （鄂卫2015-53）
This study is supported by the Plan Project of Hubei Provincial Health Department (grant No.hb2015-53). （grant No.hb2015-53）
