海南医学院学报2017，Vol.23Issue(13)：1805-1808,4.DOI:10.13210/j.cnki.jhmu.20170628.006
甲状腺激素对体外循环下瓣膜置换术中心肌及脑组织缺血再灌注损伤的影响
Effect of euthyrox on myocardial and cerebral ischemia reperfusion injury in valve replacement under cardiopulmonary bypass
摘要
Abstract
Objective:To study the effect of euthyrox on myocardial and cerebral ischemia reperfusion injury in valve replacement under cardiopulmonary bypass.Methods:A total of 76 patients who received valve replacement under cardiopulmonary bypass in our hospital between January 2013 and December 2016 were collected and divided into control group (n=38) and observation group (n=38) according to random number table.One week before surgery,patients in observation group took euthyrox orally(50 μg/d),while patients in control group took vitamin C tablets (1 tablet/d),and both therapies lasted for 1 week until the morning of surgery day.Before medication and after cardiopulmonary bypass (before the end of surgery),serum levels of myocardial enzyme spectrum indexes and nerve injury indexes were compared between the two groups of patients.Results:Before medication,differences in the serum levels of myocardial enzyme spectrum indexes and nerve injury indexes were not statistically significant between the two groups of patients (P>0.05).After cardiopulmonary bypass,serum myocardial enzyme spectrum indexes cTnT,CK-MB,α-HBD and LDH levels in observation group were significantly lower than those in control group;serum nerve injury indexes NSE,S100B and GFAP levels were lower than those in control group while bFGF level was significantly higher than that in control group (P<0.05).Conclusions:Euthyrox intervention in valve replacement under cardiopulmonary bypass can effectively reduce the myocardial and cerebral ischemia reperfusion injury.关键词
瓣膜置换术/体外循环/甲状腺激素/缺血再灌注损伤Key words
Valve replacement/Cardiopulmonary bypass/Euthyrox/Ischemia reperfusion injury分类
医药卫生引用本文复制引用
魏庆彬,谢飞,王士礼,李刚..甲状腺激素对体外循环下瓣膜置换术中心肌及脑组织缺血再灌注损伤的影响[J].海南医学院学报,2017,23(13):1805-1808,4.基金项目
黑龙江省中医药科研项目 (ZHY16-111) （ZHY16-111）
This study was supported by Chinese Tradidtional Medicine Research Project of Heilongjiang(Grant No.ZHY16-111). （Grant No.ZHY16-111）
