海南医学院学报2017，Vol.23Issue(13)：1867-1869,1873,4.DOI:10.13210/j.cnki.jhmu.20170627.025
癫痫患者血清Hcy 代谢与神经细胞因子、凋亡分子含量的相关性
Correlation of serum Hcy metabolism with nerve cytokine and apoptosis molecule levels in patients with epilepsy
摘要
Abstract
Objective:To study the correlation of serum homocysteine (Hcy) metabolism with nerve cytokine and apoptosis molecule levels in patients with epilepsy.Methods:Patients with epileptic seizures and non-epileptic seizures who were treated in our hospital between January 2014 and December 2016 were selected as epileptic seizure group and non-epileptic seizure group respectively,and healthy volunteers during the same period were selected as control group.The serum was collected to determine the levels of Hcy metabolism indexes,nerve cytokines and apoptosis molecules.Results:Serum Hcy,BDNF,NGF,NSE,IGF-I,Bax,Caspase-3,MDA and 8-OHdG levels of epileptic seizure group were significantly higher than those of non-epileptic seizure group and control group while VitB12,Fol and Bcl-2 levels were significantly lower than those of non-epileptic seizure group and control group;serum Hcy,VitB12,Fol,BDNF,NGF,NSE,IGF-I,Bcl-2,Bax,Caspase-3,MDA and 8-OHdG levels of non-epileptic seizure group were not significantly different from those of control group;serum Hcy level in patients with epileptic seizure was positively correlated with BDNF,NGF,NSE,IGF-I,Bax,Caspase-3,MDA and 8-OHdG levels,and negatively correlated with Bcl-2 level while VitB12 and Fol levels were negatively correlated with BDNF,NGF,NSE,IGF-I,Bax,Caspase-3,MDA and 8-OHdG levels,and positively correlated with Bcl-2 level.Conclusion:Abnormal serum Hcy metabolism in patients with epileptic seizures can aggravate the neuron injury and apoptosis.关键词
癫痫/同型半胱氨酸/细胞因子/凋亡/氧化应激Key words
Epilepsy/Homocysteine/Cytokine/Apoptosis/Oxdative stress分类
医药卫生引用本文复制引用
郭微娟,杨柳,武东,邓北珍,朱亚敏,展淑琴..癫痫患者血清Hcy 代谢与神经细胞因子、凋亡分子含量的相关性[J].海南医学院学报,2017,23(13):1867-1869,1873,4.基金项目
2016年陕西省社会发展科技攻关项目(2016SF-020) （2016SF-020）
This study is supported by Social Development Scientific and Technological Programs of Shaanxi Province(grant No.2016SF-020). （grant No.2016SF-020）
