海南医学院学报2017，Vol.23Issue(14)：1889-1891,1895,4.DOI:10.13210/j.cnki.jhmu.20170628.003
纤维支气管镜下氨溴索肺泡灌洗对重症肺炎合并呼吸衰竭患者SIRS及靶器官功能损伤的影响
Effect of fiberoptic bronchoscopic bronchoalveolar lavage with ambroxol on SIRS and target organ damage in patients with severe pneumonia complicated by respiratory failure
摘要
Abstract
Objective: To study the effect of fiberoptic bronchoscopic bronchoalveolar lavage with ambroxol on the systemic inflammatory response syndrome (SIRS) and target organ damage in patients with severe pneumonia complicated by respiratory failure.Methods: A total of 68 patients with severe pneumonia complicated by respiratory failure who received inpatient treatment in our hospital between July 2013 and December 2016 were collected and then divided into control group (n=35) and observation group (n=33).Patients in control group were treated by conventional therapy while those in observation group were treated by fiberoptic bronchoscopic bronchoalveolar lavage with ambroxol plus conventional therapy.The differences of the systemic inflammatory response as well as cardiac and liver function before and after treatment were compared between two groups of patients.Results: Before treatment, differences in serum levels of inflammatory factors, myocardial enzyme spectrum and liver function indexes of patients in two groups were not statistically significant (P>0.05).After treatment, serum inflammatory factors IL-6, IL-8, TNF-α and CRP levels in observation group were lower than those in control group;serum myocardial enzyme spectrum LDH, α-HBDH, CKMB and cTnⅠ levels were lower than those in control group;serum liver function index(Alb)content was higher than that in control group while ALP, TBA, ALT and AST contents were lower than those in control group (P<0.05).Conclusions: Fiberoptic bronchoscopic bronchoalveolar lavage with ambroxol can effectively reduce the degree of SIRS, and also decrease the cardiac and liver function injury in patients with severe pneumonia complicated by respiratory failure.关键词
重症肺炎/呼吸衰竭/肺泡灌洗/炎症反应Key words
Severe pneumonia/Respiratory failure/Bronchoalveolar lavage/Inflammatory response分类
医药卫生引用本文复制引用
邓小军,杨丽萍..纤维支气管镜下氨溴索肺泡灌洗对重症肺炎合并呼吸衰竭患者SIRS及靶器官功能损伤的影响[J].海南医学院学报,2017,23(14):1889-1891,1895,4.基金项目
四川省教育厅资助项目(15zb028)This study was supported by Education Department of Sichuan Province (Grant No.15zb028) （15zb028）
