海南医学院学报2017，Vol.23Issue(14)：1892-1895,4.DOI:10.13210/j.cnki.jhmu.20170723.004
重症急性胰腺炎患者血清炎性因子含量与全身靶器官损伤的关系研究
Study on the relationship between serum inflammatory factors and systemic target organ damage in patients with severe acute pancreatitis
摘要
Abstract
Objective: To study the relationship between serum inflammatory factor levels and systemic target organ damage in patients with severe acute pancreatitis.Methods: A total of 85 patients who were diagnosed with severe acute pancreatitis in the Second Affiliated Hospital of Xi'an Jiaotong University between June 2013 and August 2016 were enrolled in SAP group, and 100 healthy volunteers who received physical examination during the same period were enrolled in control group.Then serum inflammatory factors, liver function injury indexes, renal function injury indexes and intestinal mucosal barrier function indexes as well as urine renal function injury indexes were determined.Results: Serum PCT, TNF-α, CRP, HMGB-1, ALT, AST, TBIL, BUN, Scr, CysC, DAO, D-lactate, Occludin and ZO-1 levels as well as urine NGAL and KIM-1 levels of SAP group were significantly higher than those of control group;serum PCT, TNF-α, CRP and HMGB-1 levels of patients with SAP were positively correlated with serum ALT, AST, TBIL, BUN, Scr, CysC, DAO, D-lactate, Occludin and ZO-1 levels as well as urine NGAL and KIM-1 levels.Conclusions: Abnormal release of inflammatory factors in serum of SAP patients can cause the injury of liver function, renal function and intestinal mucosal barrier function.关键词
重症急性胰腺炎/炎性因子/肝功能/肾功能/肠黏膜屏障Key words
Severe acute pancreatitis/Inflammatory factor/Liver function/Renal function/Intestinal mucosal barrier分类
医药卫生引用本文复制引用
翟宏军,张心武,孙晓力,马双余..重症急性胰腺炎患者血清炎性因子含量与全身靶器官损伤的关系研究[J].海南医学院学报,2017,23(14):1892-1895,4.基金项目
陕西省科技攻关项目(2014K12-13-09) It is supported by Project for Science and Technology Development of Shaanxi Province (2014K12-13-09). （2014K12-13-09）
