海南医学院学报2017，Vol.23Issue(14)：1918-1921,4.DOI:10.13210/j.cnki.jhmu.20170809.009
硬膜外麻醉联合全凭静脉麻醉对腹腔镜术中及术后应激反应、凝血功能的影响
Effect of epidural anesthesia combined with total intravenous anesthesia on stress response and coagulation function in and after laparoscopic surgery
摘要
Abstract
Objective: To study the effect of epidural anesthesia combined with total intravenous anesthesia on stress response and coagulation function in and after laparoscopic surgery.Methods: A total of 219 patients who received laparoscopic cholecystectomy in our hospital between August 2014 and February 2017 were collected and divided into control group (n=125) who accepted total intravenous anesthesia alone and observation group (n=94) who accepted epidural anesthesia combined with total intravenous anesthesia.Perioperative stress response and coagulation function were compared between two groups of patients.Results: Before operation, differences in serum stress index contents and peripheral blood coagulation index levels were not statistically significant between two groups of patients (P>0.05).In operation and 2 hours after operation, serum stress indexes Cor, Ang-Ⅰ, Ang-Ⅱ and NE contents of observation group were significantly lower than those of control group (P<0.05);peripheral blood coagulation indexes PT, TT and APTT levels were significantly higher than those of control group (P<0.05) while TXA2, TXB2 and FBG levels were significantly lower than those of control group (P<0.05).Conclusions: Epidural anesthesia combined with total intravenous anesthesia can effectively alleviate systemic stress response and reduce hypercoagulable state in and early after laparoscopic surgery.关键词
腹腔镜/硬膜外麻醉/全凭静脉麻醉/应激反应/凝血功能Key words
Laparoscopy/Epidural anesthesia/Total intravenous anesthesia/Stress response/Coagulation function分类
医药卫生引用本文复制引用
宋国军..硬膜外麻醉联合全凭静脉麻醉对腹腔镜术中及术后应激反应、凝血功能的影响[J].海南医学院学报,2017,23(14):1918-1921,4.基金项目
陕西省科学技术研究发展计划 (2013k-09-06)This study was supported by Shaanxi Provincial Science and Technology Research and Development Planning Project (Grant No.2013k-09-06) （2013k-09-06）
