海南医学院学报2017，Vol.23Issue(14)：1938-1940,1944,4.DOI:10.13210/j.cnki.jhmu.20170809.011
阿奇霉素与甘草锌联合治疗对支原体肺炎患儿炎症反应程度及免疫应答功能的影响
Effect of azithromycin combined with licorzinc therapy on inflammatory response and immune response in children with mycoplasma pneumonia
摘要
Abstract
Objective: To study the effect of azithromycin combined with licorzinc therapy on inflammatory response and immune response in children with mycoplasma pneumonia.Methods: A total of 150 children with mycoplasma pneumonia who were treated in our hospital between January 2014 and January 2017 were collected and divided into control group and observation group according to the random number table, with 75 cases in each group.Control group received azithromycin therapy while observation group received azithromycin combined with licorzinc therapy, and both therapies lasted for 14 days.The differences in serum levels of inflammatory factors, Th17/Treg cytokines and immunoglobulin were compared between the two groups before and after treatment.Results: Before treatment, differences in serum levels of inflammatory factors, Th17/Treg cytokines and immunoglobulin were not statistically significant between two groups of patients (P>0.05).After treatment, serum inflammatory factors IL-6, IL-12, IL-13 and MCP-4 levels of observation group were significantly lower than those of control group (P<0.05);serum Th17/Treg cytokines IL-17 and IL-25 levels were significantly lower than those of control group (P<0.05) while IL-10 and IL-35 levels were significantly higher than those of control group (P<0.05);serum immunoglobulin IgA, IgG and IgM levels were significantly higher than those of control group (P<0.05).Conclusions: Azithromycin combined with licorzinc therapy can effectively reduce systemic inflammatory response and optimize immune function in children with mycoplasma pneumonia.关键词
支原体肺炎/阿奇霉素/甘草锌/炎症反应/免疫应答Key words
Mycoplasma pneumonia/Azithromycin/licorzinc/Inflammatory response/Immune response分类
医药卫生引用本文复制引用
柴巧利..阿奇霉素与甘草锌联合治疗对支原体肺炎患儿炎症反应程度及免疫应答功能的影响[J].海南医学院学报,2017,23(14):1938-1940,1944,4.基金项目
陕西省卫计委科研项目(2016D076)This study was supported by the Research Project of Shaanxi Provincial Health and Family Planning Commission (Grant No.2016D076) （2016D076）
