海南医学院学报2017，Vol.23Issue(14)：1957-1960,4.DOI:10.13210/j.cnki.jhmu.20170721.008
胃癌患者血清sLAG-3、PARP-1、CA50含量与手术切除病灶中癌基因表达的相关性
Correlation of serum sLAG-3, PARP-1 and CA50 levels with oncogene expression in surgically removed lesions in patients with gastric cancer
摘要
Abstract
Objective: To study the correlation of serum sLAG-3, PARP-1 and CA50 levels with oncogene expression in surgically removed lesions in patients with gastric cancer.Methods: A total of 98 patients who were diagnosed with gastric cancer in Zhouzhi County People's Hospital between June 2015 and March 2017 were selected as gastric cancer group, and 60 healthy volunteers who received physical examination during the same period were selected as control group.The serum was collected from the two groups to determine the contents of sLAG-3, PARP-1 and CA50;gastric cancer lesions and adjacent lesions were collected from gastric cancer group to determine protein expression of PDCD4, RASSF1A, p16ink4a, Kiss-1, Eaf-2, CDC4, UHRF1, OCT4, Zeb-1 and c-jun.Results: Serum sLAG-3, PARP-1 and CA50 levels of gastric cancer group were significantly higher than those of control group(P<0.05)and the higher the TNM stage , the higher the serum sLAG-3, PARP-1 and CA50 levels were(P<0.05);PDCD4, RASSF1A, p16ink4a, Kiss-1, Eaf-2 and CDC4 protein levels in gastric cancer lesions were significantly lower than those in adjacent lesions (P<0.05)and negatively correlated with serum sLAG-3, PARP-1 and CA50 levels while UHRF1, OCT4, Zeb-1 and c-jun protein levels in gastric cancer lesions were significantly higher than those in adjacent lesions (P<0.05)and positively correlated with serum sLAG-3, PARP-1 and CA50 levels.Conclusions: The increase of serum sLAG-3, PARP-1 and CA50 levels in patients with gastric cancer is closely related to pathological process of gastric cancer, deletion of tumor suppressor gene expression and increase of proto-oncogene expression.关键词
胃癌/可溶性淋巴细胞活化基因-3(sLAG-3)/多聚ADP-核糖聚合酶-1(PARP-1)/糖类抗原50(CA50)/增殖Key words
Gastric cancer/Soluble lymphocyte activationgene-3/Poly ADP-ribose polymerase-1/Carbohydrate antigen 50/Proliferation分类
医药卫生引用本文复制引用
马乐群,李新房,王斌..胃癌患者血清sLAG-3、PARP-1、CA50含量与手术切除病灶中癌基因表达的相关性[J].海南医学院学报,2017,23(14):1957-1960,4.基金项目
陕西省科学技术研究发展计划项目(2011k13-02-06)This study was supported by Shannxi Provincial Science and Technology Research and Development Project (Grant No.2011k13-02-06) （2011k13-02-06）
