海南医学院学报2017，Vol.23Issue(14)：1961-1964,1968,5.DOI:10.13210/j.cnki.jhmu.20170721.009
全身静脉化疗联合区域动脉灌注化疗栓塞对局部进展期胃癌恶性程度的影响
Effect of systemic intravenous chemotherapy combined with regional arterial perfusion chemoembolization on the malignancy of locally advanced gastric cancer
摘要
Abstract
Objective: To study the effect of systemic intravenous chemotherapy combined with regional arterial perfusion chemoembolization on the malignancy of locally advanced gastric cancer.Methods: A total of 90 patients with primary gastric cancer who received treatment in Tianyou Hospital Affiliated to Wuhan University of Science & Technology were collected and divided into control group and observation group according to the random number table method, 45 cases in each group.The control group of patients received routine systemic intravenous chemotherapy and surgical treatment, and the observation group of patients received systemic intravenous chemotherapy combined with local arterial perfusion chemoembolization and surgical treatment.Levels of tumor markers and angiogenesis factors in serum as well as the expression of oncogenes and tumor suppressor genes in gastric cancer tissue were compared between the two groups of patients before and after chemotherapy.Results: Before chemotherapy, the levels of tumor markers and angiogenesis factors in serum as well as the expression of oncogenes and tumor suppressor genes in gastric cancer tissue were not significantly different between the two groups of patients;after chemotherapy, serum CEA, CA724, CA242, AFP, VEGF, Ang-2, COX2 and PD-ECGF levels of observation group were lower than those of control group, and iASPP, p130Cas, ERBB2 and C-myc mRNA expression in gastric cancer tissue were lower than those of control group while GKN1, p16, PTEN, TSPYL5 and merlin mRNA expression in gastric cancer tissue were higher than those of control group.Conclusions: Preoperative systemic intravenous chemotherapy combined with regional arterial perfusion chemoembolization can effectively reduce the malignancy of locally advanced gastric cancer and provide favorable conditions for the operation.关键词
局部进展期胃癌/全身静脉化疗/区域动脉灌注化疗/肿瘤标志物/癌基因Key words
Locally advanced gastric cancer/Systemic intravenous chemotherapy/Regional arterial perfusion chemoembolization/Tumor markers/Oncogene分类
医药卫生引用本文复制引用
王强,吴刚..全身静脉化疗联合区域动脉灌注化疗栓塞对局部进展期胃癌恶性程度的影响[J].海南医学院学报,2017,23(14):1961-1964,1968,5.基金项目
湖北省科学技术厅项目(EK110281)It is supported by Science and Technology Department of Hubei Province (EK110281). （EK110281）
