海南医学院学报2017，Vol.23Issue(14)：1965-1968,4.DOI:10.13210/j.cnki.jhmu.20170726.006
新辅助化疗+营养干预对结肠癌不全性肠梗阻患者营养状况、肿瘤负荷的影响
Effect of neoadjuvant chemotherapy + nutritional intervention on the nutritional status and tumor load in colon cancer patients with incomplete ileus
摘要
Abstract
Objective: To explore the effect of neoadjuvant chemotherapy + nutritional intervention on the nutritional status and tumor load in colon cancer patients with incomplete ileus.Methods: A total of 90 patients with middle and advanced colon cancer who were treated in the hospital were divided into control group and observation group by random number table, each with 45 cases.Control group received routine neoadjuvant chemotherapy + surgical treatment, and the observation group received nutritional intervention on this basis.The differences in nutritional status and tumor load between the two groups were compared before neoadjuvant chemotherapy (T0), after neoadjuvant chemotherapy (T1) and three days after opeartion (T2).Results: At T0, the differences in the contents of nutrition indexes in peripheral blood as well as the contents of specific tumor markers and angiogenesis indexes were not statistically significant between the two groups (P>0.05).At T1 and T2, peripheral blood nutrition indicators TB, Alb and Hb contents of observation group were higher than those of control group;serum specific tumor markers PTN and CCSA-1 contents were lower than those of control group;serum angiogenesis indexes VEGF and Ang-2 contents were lower than those of control group (P<0.05).Conclusions: Neoadjuvant chemotherapy + nutrition intervention can effectively improve the nutritional status of colon cancer patients with incomplete ileus, and help to further reduce the tumor load.关键词
结肠癌/不全性肠梗阻/新辅助化疗/营养干预/肿瘤负荷Key words
Colon cancer/Incomplete ileus/Neoadjuvant chemotherapy/Nutrition intervention/Tumor load分类
医药卫生引用本文复制引用
杨露,吴棠..新辅助化疗+营养干预对结肠癌不全性肠梗阻患者营养状况、肿瘤负荷的影响[J].海南医学院学报,2017,23(14):1965-1968,4.基金项目
四川省科技局课题项目(100732)It is supported by Project of Science and Technology Bureau of Sichuan Province (100732). （100732）
