海南医学院学报2017，Vol.23Issue(14)：1991-1994,4.DOI:10.13210/j.cnki.jhmu.20170723.010
超声造影定量参数与肝癌细胞增殖活力、病灶内血管新生的相关性研究
The correlation of the quantitative ultrasonography parameters with the liver cancer cell proliferation activity and intralesional angiogenesis
摘要
Abstract
Objective: To study the correlation of the quantitative ultrasonography parameters with liver cancer cell proliferation activity and intralesional angiogenesis.Methods: A total of 46 patients with liver cancer who received surgical resection in Hancheng People's Hospital as well as 28 patients who received partial hepatectomy for abdominal trauma during the same period were selected, the patients with liver cancer received ultrasonography, and the quantitative parameters were calculated;the liver cancer tissue and adjacent tissue of patients with liver cancer as well as the normal liver tissue of patients with abdominal trauma were collected to determine the expression of proliferation genes, tumor suppressor genes and angiogenesis genes.Results: The IMAX of liver cancer tissue was significantly higher than that of adjacent tissue while the TTP, WT and mTT were significantly shorter than those of adjacent tissue;RNF180, Merlin, PICK1 and PTEN protein expression in liver cancer tissue and adjacent tissue were significantly lower than those in normal liver tissue, negatively correlated with the IMAX of liver cancer tissue, and positively correlated with the TTP, WT and mTT of liver cancer tissue;EphB4, SALL4, Cripto-1, VEGF, PDGF, EGFR and Ang-2 protein expression in liver cancer tissue and adjacent tissue were significantly higher than those in normal liver tissue, positively correlated with the IMAX of liver cancer tissue, and negatively correlated with the TTP, WT and mTT of liver cancer tissue.Conclusions: The changes in the quantitative parameters of liver cancer ultrasonography are valuable for evaluating the cell proliferation and angiogenesis.关键词
肝癌/超声造影/增殖/凋亡/血管新生Key words
Liver cancer/Ultrasonography/Proliferation/Apoptosis/Angiogenesis分类
医药卫生引用本文复制引用
路红涛,陈艳玲..超声造影定量参数与肝癌细胞增殖活力、病灶内血管新生的相关性研究[J].海南医学院学报,2017,23(14):1991-1994,4.基金项目
陕西省卫计委(2014D30)It is supported by Health and Family Planning Commission of Shaanxi Province (2014D30). （2014D30）
