海南医学院学报2017，Vol.23Issue(14)：2006-2009,2013,5.DOI:10.13210/j.cnki.jhmu.20170723.001
康复训练联合神经营养治疗对脑外伤患者康复期神经细胞因子分泌及氧化应激反应的影响
Effect of rehabilitation training combined with neurotrophic therapy on the nerve cytokine secretion and oxidative stress in rehabilitation period of patients with traumatic brain injury
摘要
Abstract
Objective: To study the effect of rehabilitation training combined with neurotrophic therapy on the nerve cytokine secretion and oxidative stress in rehabilitation period of patients with traumatic brain injury.Methods: A total of 98 patients in rehabilitation period of traumatic brain injury who were treated in our hospital between July 2013 and September 2016 were collected and divided into control group and observation group according to the random number table method, 49 cases in each group.Control group received regular neurotrophic therapy, and observation group received rehabilitation training combined with neurotrophic therapy.The differences in the contents of nerve cytokines and oxidative stress indexes were compared between the two groups before and after intervention.Results: Before intervention, differences in serum levels of nerve injury indexes, neurotrophy indexes, amino acid neurotransmitters and oxidative stress indexes were not statistically significant between the two groups of patients (P>0.05).After intervention, serum nerve injury indexes MBP, NGB, NSE and S-100B levels as well as excitatory amino acids Glu and Asp levels of observation group were significantly lower than those of control group (P<0.05) while neurotrophy indexes BDNF and GDNF levels as well as inhibitory amino acids GABA and Gly levels were significantly higher than those of control group (P<0.05);serum oxidative stress indexes SOD and CAT levels were higher than those of control group while MDA level was significantly lower than that of control group (P<0.05).Conclusion: Rehabilitation training combined with neurotrophic therapy can effectively optimize the nerve function and reduce the systemic oxidative stress state of patients in rehabilitation period of traumatic brain injury.关键词
脑外伤康复期/康复训练/神经营养治疗/氧化应激Key words
Rehabilitation period of traumatic brain injury/Rehabilitation training/Neurotrophic therapy/Oxidative stress分类
医药卫生引用本文复制引用
代高英,张诚..康复训练联合神经营养治疗对脑外伤患者康复期神经细胞因子分泌及氧化应激反应的影响[J].海南医学院学报,2017,23(14):2006-2009,2013,5.基金项目
四川省医学会课题项目(Q15029)This study is supported by Medical Association Research Project of Sichuan Province (grant No.Q15029). （Q15029）
