海南医学院学报2017，Vol.23Issue(14)：2017-2020,4.DOI:10.13210/j.cnki.jhmu.20170809.031
局部臭氧治疗对肛瘘创面中炎症细胞因子、生长细胞因子及凋亡分子表达的影响
Effect of local ozone treatment on inflammatory cytokine, growth cytokine and apoptosis molecule expression in anal fistula wound
摘要
Abstract
Objective: To study the effect of local ozone treatment on inflammatory cytokine, growth cytokine and apoptosis molecule expression in anal fistula wound.Methods: Patients with low simple anal fistula who received anal fistulectomy in the Eighth Hospital of Wuhan between June 2014 and December 2016 were selected and randomly divided into ozone group and control group who received ozone combined with routine treatment and routine treatment respectively.Five days, ten days and fifteen days after treatment, the proper amount of wound granulation tissue was clamped to determine the expression of inflammatory cytokines IFN-γ, TNF-α, IL-1, IL-8 and IL-12, growth cytokines VEGF, FGF-1, FGF-2 and EGF as well as apoptosis molecules Bax, P53 and caspase-3.Results: Five days, ten days and fifteen days after treatment, IFN-γ, TNF-α, IL-1, IL-8, IL-12, VEGF, FGF-1, FGF-2 and EGF protein expression in anal fistula wound of ozone group were significantly higher than those of control group (P<0.05) while Bax, P53 and caspase-3 protein expression were significantly lower than those of control group (P<0.05).Conclusions: Local ozone treatment can increase the expression of inflammatory cytokines and growth cytokines, inhibit the expression of apoptosis molecules in anal fistula wound, and promote wound healing.关键词
肛瘘/创面/臭氧/细胞因子/凋亡Key words
Anal fistula/Wound/Ozone/Cytokines/Apoptosis分类
医药卫生引用本文复制引用
卢勇,吕雪丽,黄成龙,徐跃军..局部臭氧治疗对肛瘘创面中炎症细胞因子、生长细胞因子及凋亡分子表达的影响[J].海南医学院学报,2017,23(14):2017-2020,4.基金项目
2013湖北省卫计委面上项目(JX6B105)This study was supported by 2013 Hubei Provincial Health and Family Planning Commission (Grant No.JX6B105) （JX6B105）
