华西口腔医学杂志2017，Vol.35Issue(4)：437-441,5.DOI:10.7518/hxkq.2017.04.018
孕期健康和环境暴露对牙发育的影响
Effect of maternal health and prenatal environmental exposure factors on tooth development
摘要
Abstract
Odontogenesis is a consequence of a complex series of reciprocal signal interactions between odontogenic epi-thelium and neural crest-derived odontotgenic mesenchyme. These interactions result from a complex interplay of genetic and environmental factors. Given that a fetus develops in the mother, maternal health and environmental exposures have a great influence on tooth development. In this review, we focused on the key issues in the developmental defects of teeth induced by various types of maternal environmental factors, including environmental endocrine disruptors, joint action of two or more chemical exposures, and maternal health status. This review also discussed the adverse effects of maternal environmental factors on tooth development. These effects include enamel developmental defects, molar incisor hypomineralization, dental fluorosis, hyperdontia and hypodontia. Overall, this review provides a theoretical basis for the prevention of tooth defects in early life, assessment of risks from developmental tooth defects, and advancement of pediatric oral health management.关键词
牙发育/孕期健康/环境因素/环境内分泌干扰物Key words
odontogenesis/maternal health/environmental factors/environmental endocrine disruptors分类
医药卫生引用本文复制引用
万冕,周学东,郑黎薇..孕期健康和环境暴露对牙发育的影响[J].华西口腔医学杂志,2017,35(4):437-441,5.基金项目
国家自然科学基金面上项目(81470711,81371136)National Natural Science Foundation of China, General Project (81470711, 81371136). （81470711,81371136）
