基础医学与临床2017，Vol.37Issue(7)：1000-1003,4.
中性粒细胞/淋巴细胞比值对血流感染的诊断价值
Value of neutrophil-lymphocyte count ratio in diagnosing bloodstream infection
摘要
Abstract
Objective To explore the diagnostic value of five infection markers in bloodstream infection.Methods Randomly selected 110 bloodstream infection patients with positive blood cultures and 30 bacterial infection patients with negative blood cultures.Blood was simultaneously drawn with blood cultures;the complete blood count and C-reactive protein (CRP) levels were measured.The white blood cell count (WBC),neutrophil count (NEU),lymphocyte count (LMY),CRP level and neutrophil-lymphocyte count ratio (NLCR) were compared between the two groups.Results The levels of WBC,NEU,NLCR and CRP in bloodstream infection group were significantly higher than those in control group (P＜0.05),while LYM was significantly lower than that in control group (P＜ 0.05).Among these five infection markers,the area under the receiver operating characteristic curve (ROC-AUC) was the highest for NLCR (0.808) and LMY (0.756);when the cutoff value for NLCR was ＞9.33,sensitivity was 63.6％,specificity was 93.3％;and the cutoff value for LYM was ≤0.97,sensitivity was 58.2％,specificity was 86.7％.Furthermore,the NLCR of patients with gram-negative bloodstream infection was higher than those in patients with gram-positive bloodstream infection.NLCR showed important clinical significance in distinguishing strains of different bloodstream infections.Conclusions NLCR is the better predictors than routine parameters in diagnosing bloodstream infection.关键词
中性粒细胞/淋巴细胞比值/血流感染Key words
neutrophil-lymphocyte count ratio/bloodstream infection分类
医药卫生引用本文复制引用
申丽红,陈永德,朝浩鹏,宋文琪,田晓怡..中性粒细胞/淋巴细胞比值对血流感染的诊断价值[J].基础医学与临床,2017,37(7):1000-1003,4.基金项目
首都医科大学附属北京儿童医院苗圃计划(BCHYIPB-2016-01) （BCHYIPB-2016-01）
