扬州大学学报（农业与生命科学版）2017，Vol.38Issue(2)：28-31,46,5.DOI:10.16872/j.cnki.1671-4652.2017.02.006
利用有理样条插值法计算EC50的研究
Study on calculation of EC50 by rational spline interpolation method
摘要
Abstract
With the application of a case involving two typical toxicity data,the paper took the control data into the calculation process,calculated the expression of rational spline interpolation and draw the curve for the concentrationinhibition ratio by rational spline interpolation.The EC50 was compared with the results of the methods of curve-fitting,probit method,etc.The result indicated that the method of rational spline interpolation was a new method to calculate EC50,which established optimal mathematical model based on minimum strain energy,and was suitable for the case of less experimental data.关键词
EC50/有理三次样条插值/保形/曲线拟合/概率单元法Key words
EC50/rational cubic spline interpolation/shape preserving/curve fitting/probit method分类
数理科学引用本文复制引用
朱涛,张澜,赵前进..利用有理样条插值法计算EC50的研究[J].扬州大学学报（农业与生命科学版）,2017,38(2):28-31,46,5.基金项目
国家自然科学基金资助项目(60973050) （60973050）
