解放军医学院学报2017，Vol.38Issue(7)：595-597,627,4.DOI:10.3969/j.issn.2095-5227.2017.07.001
2型糖尿病患者血清25(OH)D与血脂相关性研究
Association of serum 25-hydroxy vitamin D with lipid profiles in patients with type 2 diabetes mellitus
摘要
Abstract
Objective To explore the relationship between serum 25-hydroxy vitamin D and lipid profiles in patients with type 2 diabetes mellitus (T2DM).Methods This cohort included 408 patients diagnosed as T2DM from a large epidemiological survey database.After medical history taking and physical examination,every patient underwent serum biochemical tests and then were divided into three groups:normal [25(OH)D ＞ 50 nmol/L],insufficient [25 ＜ 25(OH)D ＜ 50 nmol/L],deficient [25(OH)D levels ＜ 25 nmol/L] according to the serum 25(OH)D level.AVONA was used to analyze and compare the lipid levels in different 25(OH) D groups,and multivariate logistic regression was used to analyze the relationship between TC,LDL and 25(OH)D.Results Both TC and LDL-C in deficient group were significant higher than those in normal and insufficient group [TC:(5.59 ± 1.0) mmol/L vs (5.26 ± 0.96) mmol/L,(5.25 ± 1.07) mmol/L,P ＜ 0.05,respectively;LDL-C:(3.71 ± 0.71) mmol/L vs (3.41 ± 0.76) mmol/L,(3.45 ± 0.84) mmol/L,P ＜ 0.05,respectively],while no significant difference was found in TG and HDL-C (PTC=0.405,PLDL-C=0.719).After adjusting age,FPG and BMI,the serum 25-hydroxy vitamin D was negatively correlated with TC and LDL-C respectively.Conclusion The TC and LDL-C are significantly different in different level of serum 25-hydroxy vitamin D groups.The serum 25-hydroxy vitamin D is negatively associated with TC and LDL-C in T2DM patients.关键词
维生素D/糖尿病/血脂Key words
vitamin D/diabetes mellitus/blood lipid分类
医药卫生引用本文复制引用
陆游,孟盈,郑彦俊,宁志远,仓桢,陆颖理..2型糖尿病患者血清25(OH)D与血脂相关性研究[J].解放军医学院学报,2017,38(7):595-597,627,4.基金项目
国家自然科学基金项目(81270885 （）
81070677) （）
国家科技部科研项目(2012CB524906) （2012CB524906）
上海市科研计划项目(14495810700 （）
12XD1403100)Supported by National Natural Science Fund Project (81270885 （）
81070677) （）
the Scientific Research Program of Ministry of Science and Technology(2012CB524906) （2012CB524906）
the Scientific Research Program of Shanghai (14495810700 （）
12XD1403100) （）
