解放军医学院学报2017，Vol.38Issue(7)：615-618,623,5.DOI:10.3969/j.issn.2095-5227.2017.07.006
中医药干预肺癌相关性失眠临床疗效观察
Traditional Chinese medicine in treatment to lung cancer related insomnia
摘要
Abstract
Objective To evaluate the effect of the method of yang yin yi qi an shen among the qi yin liang xu non-small cell lung cancer (NSCLC) insomniacs.Methods We selected 90 qi yin liang xu NSCLC insomniacs from Navy General Hospital from November 2015 to December 2016,and they were randomly divided into two groups:the traditional Chinese medicine (TCM) group in which patients were treated with Bai He Gu Jin Tang combined with Huang Lian E Jiao Tang for two weeks,and the western medicine (WM) group in which patients were treated with zolpidem for two weeks.Pittsburgh sleep quality index (PSQI) was recorded and sleep quality was monitored by Actiwatch before the treatment,at day 7 and day 14 during treatment,at day 14 after treatment.Results In total 85 patients completed our study.On the 14th day of treatment,the effective rate (TCM Group∶ 69.8％ vs WT Group∶ 69％),PSQI seore (TCM Group∶ 8 vs WT Group∶ 7.5),sleep duration (TCM Group∶ 7.1 h vs WT Group∶ 6.6 h) between the two groups had no statistically significant difference,But patients in traditional medicine group had significantly greater onset latency than those in western medicine group (38 min vs 29 min,P ＜ 0.05).On the 14th day after drug withdraw,the effective rate in traditional medicine group decreased to 55.8％,while that in westem medicine group decreased to 26.2％ (P ＜ 0.05).Besides,patients in traditional medicine group had significantly lower PSQI score (9 vs 10.5,P ＜ 0.05) and longer sleep duration (6.4 h vs 5.8 h,P ＜ 0.05).The length of onset latency between the two groups showed no significant difference.Conlusion It's effective to treat insomnia with the method of yang yin yi qi anshen by using Bai He Gu Jin Tang combined with Huang Lian E Jiao Tang among NSCLC patients.Bai He Gu Jin Tang combined with Huang Lian E Jiao Tang can lengthen the sleep duration,which is also showed by zolpidem.Bai He Gu Jin Tang combined with Huang Lian E Jiao Tang is less effective than zolpidem in reducing the time of onset latency,however,its effect lasts longer than zolpidem.关键词
非小细胞肺癌/睡眠障碍/中药Key words
non small-cell lung cancer/sleep disorders/traditional Chinese medicine分类
医药卫生引用本文复制引用
程国良,钱彦方,宋康康,李静,姜兴伟..中医药干预肺癌相关性失眠临床疗效观察[J].解放军医学院学报,2017,38(7):615-618,623,5.基金项目
国家自然科学基金项目(81102678)Supported by the National Natural Science Foundation of China (81102678) （81102678）
