解放军医学院学报2017，Vol.38Issue(7)：628-630,661,4.DOI:10.3969/j.issn.2095-5227.2017.07.009
中性粒细胞与淋巴细胞计数比在乳腺导管内乳头状肿瘤鉴别诊断中的价值
Diagnostic value of neutrophil lymphocyte ratio for intraductal papillary neoplasms of breast
吴伟 1田文 1苗欣 1沈少平 1赵永亮 1张艳君1
作者信息
摘要
Abstract
Objective To investigate the diagnostic value of neutrophil lymphocyte ratio in intraductal papillary neoplasms (IDPN) of breast.Methods Clinical data about patients diagnosed as intraductal papillary neoplasms of breast from July 2014 to June 2016 were analyzed retrospectively in Breast Disease Center,Chinese PLA General Hospital.The patients were divided into benign group and malignant group according to postoperative pathologic results,and neutrophil lymphocyte ratio (NLR),age,menopause,nipple discharge and tumor size in each group were compared.Furthermore,the optimal cut-off value of NLR in the differentiation of benign and malignant neoplasms was obtained by ROC curve.Results A total of 175 patients were diagnosed as intraductal papillary neoplasms of breast.There were 122 (69.71％) cases diagnosed as intraductal papilloma and 53 (30.29％) cases diagnosed as intraductal papillary carcinoma.NLR values were (1.76 ± 0.78) in benign group and (2.60 ± 1.14) in malignant group,respectively (P ＜ 0.05).NLR was the main factor associated with the classification ofIDPN (P ＜ 0.05).The optimal NLR cut-off value obtained from ROC analysis was 1.90 with AUC of 0.766,sensitivity of 77.40％,specificity of 67.20％,positive predictive value of 84.45％ and diagnostic accuracy of 74.31％,respectively.Conclusion Preoperative NLR is helpful to differentiate malignant intraductal papillary neoplasm of breast from benign tumor,and high NLR is a significant diagnostic predictor of breast cancer.关键词
导管内乳头状肿瘤/乳腺肿瘤/中性粒细胞淋巴细胞比率/鉴别诊断Key words
intraductal papillary neoplasms/breast tumor/neutrophil lymphocyte ratio/differential diagnosis分类
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吴伟,田文,苗欣,沈少平,赵永亮,张艳君..中性粒细胞与淋巴细胞计数比在乳腺导管内乳头状肿瘤鉴别诊断中的价值[J].解放军医学院学报,2017,38(7):628-630,661,4.
