解放军医学院学报2017，Vol.38Issue(7)：689-692,4.DOI:10.3969/j.issn.2095-5227.2017.07.023
M型磷脂酶A2受体及其抗体在特发性膜性肾病中作用的研究进展
Effects of M type phospholipase A2 receptors and its antibody on idiopathic membranous nephropathy
摘要
Abstract
Membranous nephropathy is the main cause of nephrotic syndrome in adults,and the pathogenesis of idiopathic membranous nephropathy (IMN) is incompletely understood.IMN lacks sensitive and specific detection index,and its treatment and prognosis still remain controversial.M type phospholipase A2 receptors (PLA2R) is considered as a serological biomarker of IMN.Both PLA2R and its antibody (anti-PLA2R) are expressed in IMN patients,which have high specificity and sensitivity.Detection of PLA2R in kidney tissues and anti-PLA2R in serum have important significance to the diagnosis,treatment and prognosis of IMN.This article reviews the latest research progress of PLA2R and its antibody in IMN,and summarizes its clinical value in IMN.关键词
M型磷脂酶A2受体/抗PLA2R抗体/特发性膜性肾病Key words
M-type phospholipase A2 receptor/anti-PLA2R/idiopathic membranous nephropathy分类
医药卫生引用本文复制引用
尚顺来,李清刚,陈香美..M型磷脂酶A2受体及其抗体在特发性膜性肾病中作用的研究进展[J].解放军医学院学报,2017,38(7):689-692,4.基金项目
国家自然科学基金项目(81170631 （）
81330019)Supported by the National Natural Science Foundation of China(81170631 （）
81330019) （）
