摘要
Abstract
Objective To discuss value of the expression of miR-126 in evaluating on the severity of bronchial asthma.Methods A total of 40 cases of patients with bronchial asthma in acute attack stage were selected as the study group,40 cases of patients with bronchial asthma in non-acute stage were selected as the control group A,40 cases of chronic bronchitis patients were selected as the control group B,30 healthy volunteers served as control group C.Peripheral blood mononuclear cells and serum samples of four groups were tested,miR-126,IL-13 levels were detected,and the results of detection were compared.Results IL-13 levels of the study group,the control group A,the control group B were significantly higher than that of the control C(P<0.012 5).MiR-126 levels of the study group and the control group were significantly higher than those of the control group B and control group C(P<0.012 5).The level of miR-126 of the study group was significantly higher than that of the control group A(P<0.012 5),there was no significant difference in miR-126 level between the control group B and the control group C(P>0.012 5).The percentage of forced expiratory volume in one second of control C was significantly higher than that of the other three groups,and the percentage of forced expiratory volume in one second of control group A and control group B were significantly higher than that of the study group(P<0.012 5).MiR-126 expression in peripheral blood mononuclear cells of patients with bronchial asthma was negatively correlated with the percentage of forced expiratory volume in one second(r=-0.718,P<0.05) and it was positively correlated with the level of serum IL-13(r=0.699,P<0.05).Area under the curve of miR-126 in diagnosis of bronchial asthma was 0.945.Conclusion MiR-126 expression increases in peripheral blood mononuclear cells of patients with bronchial asthma,and the level of miR-126 expression is closely related to the level of inflammatory factors in patients with lung function,with the severer of illness increasing,and with the remission of the disease decreasing.It can be used to evaluate the bronchial asthma severity index.关键词
支气管哮喘/miR-126/外周血单个核细胞/急性期Key words
bronchial asthma/miR-126/peripheral blood mononuclear cells/acute stage
