临床输血与检验2017，Vol.19Issue(4)：321-324,4.DOI:10.3969/j.issn.1671-2587.2017.04.003
曲古菌素A联合全反式维甲酸诱导卵巢癌SK0V-3细胞株凋亡的研究
Trichostatin A Combined with All-trans Retinoic Acid Induce Apoptosis in Human Ovarian Cancer Cell Line SKOV-3
盛佳佳 1刘雨生1
作者信息
- 1. 230001 合肥,安徽医科大学附属妇幼保健院,安徽省妇幼保健院
- 折叠
摘要
Abstract
Objective To investigate the apoptotic effect on human ovarian cancer cells by both Trichostatin A (TSA)and all-trans retinoic acid(ATRA)and synergistic effect. Methods SKOV-3 cells were treated by different group of TSA and ATRA. The inhibitory rate of proliferation and the apoptosis rate were examined. Western blot was introduced to evaluate the protein expression levels. Results The proliferation of SKOV-3 cells was significantly suppressed by TSA combined with ATRA and the difference was significant compared with other groups (P <0.05). The apoptosis rate of combination group was higher than that of other groups and the difference was significant (P<0.05). Conclusion TSA combination with ATRA induces cytotoxicity in ovarian cancer cells in vitro,and the effect was much more significant than other groups.关键词
曲古菌素A/全反式维甲酸/细胞凋亡/SKOV-3细胞Key words
Trichostatin A/All-trans retinoic acid/Cell apoptosis/SKOV-3 cells分类
医药卫生引用本文复制引用
盛佳佳,刘雨生..曲古菌素A联合全反式维甲酸诱导卵巢癌SK0V-3细胞株凋亡的研究[J].临床输血与检验,2017,19(4):321-324,4.
