临床与实验病理学杂志2017，Vol.33Issue(6)：596-600,605,6.DOI:10.13315/j.cnki.cjcep.2017.06.002
β-catenin不同表达模式与结直肠癌临床病理因素的关系
Different expression patterns of β-catenin and its correlation with clinicopathological facters in colorectal cancer
摘要
Abstract
To observe different expression patterns of β-catenin and its clinical significance in colorectal cancer (CRC).Methods A total of 181 cases of CRC tissues and 30 cases of normal colorectal tissue were investigated by immunohistochemistry for the expression of β-catenin.Results The expression rate of β-catenin was 56.9％ (103/181) in CRC,and higher than that in normal colorectal tissue (P ＜ 0.05).The overexpression of nuclear β-catenin was significantly correlated with histological differentiation,lymph node metastasis and Dukes' stage in CRC (P ＜ 0.05),and no relationship with other pathological parameters,such as age,gender and the depth of infiltration.The incomplete membranous expression of β-catenin was significantly correlated with histological differentiation,the depth of infiltration,lymph node metastasis and Dukes' stage in CRC (P ＜ 0.05).The high expression of nuclear β-catenin related to histological differentiation and Dukes' stage in CRC (P ＜ 0.05).In the follow-up data of 82 cases of CRC,the expression of nuclear β-catenin was associated with poor prognosis,and the 5-year survival rate was significantly lower than that of self-control groups (P ＜ 0.05).Conclusion β-catenin plays important roles in colorectal carcinogenesis.Abnormal expression of β-catenin was related to the aggressive progression of CRC and may be helpful for evaluating the prognosis of patients with CRC.β-catenin is expected to become a new target for diagnosis and treatment of CRC in future.关键词
结直肠肿瘤/β-catenin/表达模式/免疫组织化学Key words
colorectal neoplasms/β-catenin/expression patterns/immunohistochemistry分类
医药卫生引用本文复制引用
金雯,陈顺华,尹玉,张聪,曹立宇..β-catenin不同表达模式与结直肠癌临床病理因素的关系[J].临床与实验病理学杂志,2017,33(6):596-600,605,6.基金项目
国家自然科学基金(81201536)、安徽省自然科学基金(KJ2013A150) （81201536）
