临床与实验病理学杂志2017，Vol.33Issue(6)：618-622,628,6.DOI:10.13315/j.cnki.cjcep.2017.06.006
食管鳞状细胞癌中HER-2基因扩增和蛋白表达
HER-2 gene amplification and protein expression in esophageal squamous cell carcinoma
摘要
Abstract
To explore the status of HER-2 gene amplification and protein expression in Chinese esophageal squamous cell carcinoma patients and its relationship with the clinicopathological parameters.Methods The HER-2 gene amplification was detected by FISH and protein expression by IHC in 96 patients with esophageal squamous cell carcinoma that would be followed up for 3 years.Results Three cases presented with 3 +,15 cases with 2 +,11 cases with 1 +,and 67 with negative by HER-2 immunohistochemical staining;2 of 3 cases presented with HER-2 amplification in in 3 +,1 case presented with over 6 HER-2 copy numbers.HER-2 amplification and HER-2 overexpression had significant correlation (P ＜ 0.000 1).HER2 amplification or overexpression was associated with clinicopathological parameters,such as,carcinomas without necrosis (P =0.012) and lower stage (P =0.040).There was better DFS or OS trend in patients with HER-2 overexpression or amplification,but the significant difference did not reached.Conclusion This research has demonstrated the correspondence between gene amplification and protein overexpression of HER-2 in ESCC.HER-2 gene overexpression or amplification is a potential better predictive parameter in ESCC,but needs further study.关键词
食管肿瘤/鳞状细胞癌/免疫组织化学/荧光原位杂交/HER-2Key words
esophageal neoplasms/squamous cell carcinoma/immunohistochemistry/fluorescence in situ hybridization/HER-2分类
医药卫生引用本文复制引用
黄洁,蒋冬先,侯英勇,纪元,徐晨,刘亚岚,刘佳,宿杰阿克苏..食管鳞状细胞癌中HER-2基因扩增和蛋白表达[J].临床与实验病理学杂志,2017,33(6):618-622,628,6.基金项目
上海市卫计委薄弱科室资助项目(2015ZB0201) （2015ZB0201）
