山东医药2017，Vol.57Issue(31)：1-4,4.DOI:10.3969/j.issn.1002-266X.2017.31.001
新疆地区维吾尔族、汉族非小细胞肺癌患者胞苷脱氨酶基因多态性对比分析
Comparision of CDA gene polymorphism between Xinjiang Uygur and Han NSCLC patients
摘要
Abstract
Objective To analyze the cytidine deaminase (CDA) gene polymorphism in Uygur and Han patients with non-small-cell lung cancer (NSCLC) in Xinjiang Uygur autonomous region.Methods Totally 120 cases of newly diagnosed advanced NSCLC patients, including 53 cases of Uygur (Uygur group) and 67 cases of Han nationality (Han group), were selected to detect the CDA A79C and G208A gene polymorphisms by direct sequencing.Results The frequencies of CDA A79C and G208A genotypes were in accordance with Hardy-Weinberg equilibrium (all P>0.05).The frequencies of A79C AA, AC, CC genotypes and A and C alleles were 75.4%, 18.9%, 5.7%, 84.9%, and 5.1%, respectively in the Uygur group, versus 52.2%, 29.9%, 17.9%, 67.2%, and 32.8% in the Han group (all P<0.05).The frequencies of G208A GG, GA genotypes and G and A alleles were 94.3%, 5.7%, 97.2%, and 2.8%, respectively in the Uygur group, versus 77.6%, 22.4%, 88.8%, and 11.2%, respectively, in the Han group (all P<0.05).Conclusion There are racial differences in the genetic polymorphisms of CDA A79C and G208A between the Uygur and Han nationalities in Xinjiang.关键词
胞苷脱氨酶/胞苷脱氨酶基因/非小细胞肺癌/基因多态性Key words
cytidinedeaminase/cytidinedeaminasegene/genepolymorphism/non-small-celllungcancer/分类
医药卫生引用本文复制引用
王艳娜,费晶,程艳芳,孟玲利,王慧,巩平..新疆地区维吾尔族、汉族非小细胞肺癌患者胞苷脱氨酶基因多态性对比分析[J].山东医药,2017,57(31):1-4,4.基金项目
国家自然科学基金资助项目(81560381) （81560381）
留学人员科技活动择优资助项目. （）
