山东医药2017，Vol.57Issue(31)：21-24,4.DOI:10.3969/j.issn.1002-266X.2017.31.006
CPB期间血氧分压在60和170 mmHg的心内直视手术患者心肝肾损伤、炎症、氧化应激指标观察
Observation of parameters of organ damage, inflammation, and oxidative stress in patients undergoing open-heart surgery during cardiopulmonary bypass with oxygen tension controlled at 60 and 170 mmHg
摘要
Abstract
Objective To compare the parameter changes of organ damage, inflammation, and oxidative stress in patients undergoing open-heart surgery during cardiopulmonary bypass with oxygen tension controlled at 60 and 170 mmHg.Methods Eighty patients undergoing open-heart surgery were randomly divided into the low oxygen tension group and high oxygen tension group with 40 patients in each.The oxygen tension in the low oxygen tension group and high oxygen tension group was 60 mmHg and 170 mmHg, respectively.The plasma was collected before surgery and at 30 min, 2 h, 6 h, 24 h after aortic declamping (T0-T4).The levels of glutamic-pyruvic transaminase (ALT), glutamic oxalacetic transaminase (AST), alkaline phosphatase (ALP), creatinine (Cr), urea nitrogen (UN), uric acid (UA) in the plasma were measured by fully automatic biochemical analyser;the levels of cardiac troponin (cTnI), creatine kinase isoenzyme (CK-MB), C-reactive protein (CRP), interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α) in the plasma were measured by ELISA;reactive oxygen (ROS), malonaldehyde (MDA) in the plasma were measured by kits.Results The levels of cTnI, CK-MB, ALT, AST, ALP, Cr, UN, and UA in the plasma of both groups increased significantly at T1-T4 as compared with those of the same group at T0 (all P<0.05);compared with the high oxygen tension group, the levels of cTnI, CK-MB, AST, ALT, ALP, Cr, UN, and UA in the low oxygen tension group at T2-T4 decreased significantly (all P<0.05).The levels of CRP, TNF-α and IL-6 increased significantly at T1-T4 as compared with those of the same group at T0 (all P<0.05);compared with the high oxygen tension group, the levels of CRP, TNF-α and IL-6 in the low oxygen tension group at T1-T4 decreased significantly (all P<0.05).The levels of ROS and MDA in both groups at T1-T4 increased significantly as compared with those of the same group at T0 (all P<0.05);compared with the high oxygen tension group, the levels of ROS and MDA in the low oxygen tension group at T1-T4 decreased significantly (all P<0.05).Conclusion Compared with the high oxygen tension, using low oxygen tension during CPB in open-heart surgery can reduce CPB-induced organ damage, inflammation, and oxidative stress significantly.关键词
体外循环/血氧分压/心内直视手术/心肝肾损伤/炎症因子/氧化应激Key words
cardiopulmonary bypass/oxygen tension/open-heart surgery/Heart/liver and kidney damage/inflammation/oxidative stress分类
医药卫生引用本文复制引用
柳磊,李召彬,李滨,徐贯杰,王园园,宋万军..CPB期间血氧分压在60和170 mmHg的心内直视手术患者心肝肾损伤、炎症、氧化应激指标观察[J].山东医药,2017,57(31):21-24,4.基金项目
河北省医学科学研究重点课题(20150731). （20150731）
