山东医药2017，Vol.57Issue(31)：25-28,4.DOI:10.3969/j.issn.1002-266X.2017.31.007
高通量血液透析终末期肾病患者口服瑞舒伐他汀、辛伐他汀后血清炎症因子和血脂水平对比观察
Comparison of changes in serum inflammatory cytokines and lipid levels after oral administration of rosuvastatin and simvastatin in patients with end-stage renal disease receiving high-throughput maintenance hemodialysis
摘要
Abstract
Objective To compare the changes in serum inflammatory cytokines and lipid levels after oral administration of rosuvastatin and simvastatin in patients with end-stage renal disease receiving high-throughput maintenance hemodialysis.Methods Seventy-eight patients with end-stage renal disease were randomly divided into the rosuvastatin group and simvastatin group.Patients in the two groups received high-throughput maintenance hemodialysis, followed by oral administration of rosuvastatin in the rosuvastatin group and simvastatin in the simvastatin group.We compared the levels of serum inflammatory cytokines [high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6)] and lipids [total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C)].Results Compared with the simvastatin group, the levels of hs-CRP, IL-6, and TNF-α decreased after treatment in the rosuvastatin group (all P<0.05).The levels of hs-CRP, IL-6, and TNF-α significantly decreased after treatment in these two groups as compared with those before treatment (all P<0.05).Compared with the simvastatin group, LDL-C decreased after treatment in the rosuvastatin group (P<0.05).The levels of TC, TG, and LDL-C significantly decreased, while HDL-C increased after treatment in these two groups as compared with those before treatment (all P<0.05).Conclusion Both rosuvastatin and simvastatin can decrease the levels of hs-CRP, TNF-α, IL-6, TC, and TG, and increase the LDL-C level, but the efficacy of rosuvastatin is better than that of simvastatin.关键词
瑞舒伐他汀/辛伐他汀/超敏C反应蛋白/肿瘤坏死因子α/白细胞介素6/总胆固醇/甘油三酯/低密度脂蛋白胆固醇/高密度脂蛋白胆固醇Key words
rosuvastatin/simvastatin/high-sensitivity C-reactive protein/tumor necrosis factor-α/interleukin-6/total cholesterol/triglyceride/low-density lipoprotein cholesterol/high-density lipoprotein cholesterol分类
医药卫生引用本文复制引用
徐芳,聂大庆,陈文莉..高通量血液透析终末期肾病患者口服瑞舒伐他汀、辛伐他汀后血清炎症因子和血脂水平对比观察[J].山东医药,2017,57(31):25-28,4.基金项目
国家自然科学基金青年基金资助项目(81400734) （81400734）
湖北省科技厅基金资助项目(2015CFB241) （2015CFB241）
武汉市卫计委基金资助项目(WZ13D08). （WZ13D08）
