实用医学杂志2017，Vol.33Issue(15)：2508-2511,4.DOI:10.3969/j.issn.1006-5725.2017.15.021
微小RNA-218在乳腺癌组织中的表达及临床意义
Expression of microRNA-218 in breast cancer and its clinical significance
摘要
Abstract
Objective To investigate the expression of miR-218 (microRNA-218) in breast cancer tissues and its clinical significance. Methods Totally 45 tissue biopsies gained from breast cancer patients and the adjacent normal tissue were collected. Real-time qPCR was used to detect the miR-218 expressions. The correlations of miR-218 expression with clinicopathological characteristics and prognosis of breast cancer patients were analyzed. Results The average expression level of miR-218 in breast cancer tissues was significantly lower than that in control tissues (P = 0.001). The average expression level of miR-218 in PR negative breast cancer tissues was significantly lower than that of PR positive breast cancer tissue (P = 0.037). The average expression level of miR-218 in Ki-67 positive breast cancer tissues was significantly lower than that in Ki-67 negative breast cancer tissue (P=0.018). Conclusion The expression of miR-218 is closely related to carcinogenesis ,progres-sion and prognosis of breast cancer ,so it may be served as a diagnostic biomarker and a prognostic predictor in breast cancer patients,which provides a new way for the treatment of breast cancer.关键词
microRNA-218/微小RNAs/基因表达/预后/Ki-67Key words
microRNA-218/microRNAs/gene expression/prognosis/Ki-67引用本文复制引用
刘擘,张立科,赵增仁,田延锋,李芳,韩晓东..微小RNA-218在乳腺癌组织中的表达及临床意义[J].实用医学杂志,2017,33(15):2508-2511,4.基金项目
河北省科技计划项目(编号:14277755D) （编号:14277755D）
