实用医学杂志2017，Vol.33Issue(15)：2558-2562,5.DOI:10.3969/j.issn.1006-5725.2017.15.035
曲美他嗪对肾功能不全患者冠脉介入术后造影剂肾病的预防作用
Preventive effect of trimetazidine on contrast - induced nephropathy in patients with chronic renal insufficiency after coronary intervention
摘要
Abstract
Objective This study was to investigate the role of trimetazidine in the prevention of contrast-induced nephropathy (CIN) in renal dysfunction patients undergoing coronary angiography. Methods A total of 151 patients with renal dysfunction who underwent coronary angiography were enrolled in our study and randomly divided into control group (n=77) and trimetazidine group (n=74). Standard hydration was administered in all the patients. In trimetazidine group, patients were administered trimetazidine orally for 48 hours before and 7 days after coronary angiography. Adverse events were observed in 12 months. Results (1) For 24 h and 48 h after the procedure:levels of SCr and CysC in the control group were significantly increased compared with baseline levels; levels of SCr and CysC in trimetazidine group were not increased, compared with baseline levels;levels of SCr and CysC were lower in trimetazidine group than the control group. (2)The incidence of CIN was reduced in trimetazidine group compared with control group (22.1%vs 9.5%,P=0.034). (3) Kaplan-Meier analysis showed that the incidence of adverse events in trimetazidine group was lower compared with the control group (P = 0.003). Conclusions Trimetazidine in combination with standard hydration is more effective than isotonic saline alone in protecting renal function in patients with renal dysfunction who undergo coronary angiography.关键词
造影剂肾病/曲美他嗪/肾功能不全/肾脏保护Key words
contrast-induced nephropathy/trimetazidine/renal dysfunction/renoprotection引用本文复制引用
樊泽元,季汉华..曲美他嗪对肾功能不全患者冠脉介入术后造影剂肾病的预防作用[J].实用医学杂志,2017,33(15):2558-2562,5.基金项目
首都临床特色应用研究基金项目(编号:Z141107002514139) （编号:Z141107002514139）
