实用医学杂志2017，Vol.33Issue(16)：2750-2753,4.DOI:10.3969/j.issn.1006-5725.2017.16.037
羟考酮用于全麻诱导时对患者血流动力学及应激反应的影响
Effect of oxycodone on hemodynamics and stress response in general anesthesia induction
摘要
Abstract
Objective To investigate the effect of oxycodone and sufentanil with equivalent dose on hemo-dynamics and stress response in general anesthesia induction. Methods One hundred and twenty ASA I orⅡpa-tients with abdominal surgery were randomly divided into oxycodone group(group O,n=60)and sufentanil group (group S,n = 60). Anesthesia was induced with iv oxycodone 0.20 mg/kg(group O)or sufentanil 0.25 μg/kg (group S)respectively,together with iv propofol 2.0 ~ 2.5 mg/kg and cisatracurium 0.2 mg/kg. The patients were tracheally intubated using a single-lumen endotracheal tube. Mean arterial pressure(MAP),heart rate(HR),plas-ma levels of epinephrine(E)and norepinephrine(NE),cortisol(Cor)and blood sugar(Glu)and the occurrence of bucking before anesthesia induction(T0),immediately before intubation(T1),at the moment of intubation(T2), 1 min(T3)and 5 min(T4)after intubation were observed. Results Compared with these at T0,MAP and HR in 2 groups were lower at T1(P<0.05)and no significant difference was found in 2 groups(P>0.05). MAP and HR were significantly higher at T2 and T3(P < 0.05)and compared with those in group O,MAP and HR in group S were increased more significantly at T2 and T3(P<0.05). MAP and HR increased slightly at T4 in 2 groups but no significant difference was found in 2 groups(P>0.05). Plasma levels of E ,NE,Cor and Glu increased obviously at T2 and T3 in 2 groups(P < 0.05)and they were even higher in group S(P < 0.05). Plasma levels of E ,NE , Cor and Glu increased slightly at T4 in 2 groups but no significant difference was found in 2 groups(P > 0.05). Conclusion Compared with sufentanil ,oxycodone of equivalent dose used for general anesthesia induction can effectively keep smooth on hemodynamics and decrease stress response.关键词
羟考酮/舒芬太尼/等效剂量/全麻诱导/血流动力学/应激反应Key words
oxycodone/sufentanil/equivalent dose/general anesthesia induction hemodynamics/stress response引用本文复制引用
孔岚,卢锡华..羟考酮用于全麻诱导时对患者血流动力学及应激反应的影响[J].实用医学杂志,2017,33(16):2750-2753,4.基金项目
河南省科技攻关计划项目(编号:162102310337) （编号:162102310337）
