实用医学杂志2017，Vol.33Issue(16)：2754-2756,3.DOI:10.3969/j.issn.1006-5725.2017.16.038
叶酸干预H型高血压患者血浆同型半胱氨酸及动脉硬化的疗效
The effect of folic acid on plasma homocysteine and atherosclerosis in patients with type H hypertension
摘要
Abstract
Objective To investigate the effect of folic acid intervention on plasma homocysteine (Hcy) metabolic changes and pulse wave velocity(PWV)in patients with type H hypertension. Methods Patients(hos-pitalized from March 2014 to December in our hospital)with H type hypertension were randomly divided into treat-ment group and control group randomly ,and were given routine antihypertensive drug therapy. Treatment group was given oral folic acid 0.8 mg,1 times a day,the control group was given placebo,1 times a day. All patient were treated for 12 months. Changes of plasma Hcy and PWV levels were observed. Results 432 patients(Han nationality)with type H hypertension were enrolled in this study with the age of 61.7 ± 13.6 years old and the ratio of men and women is 1.3:1. The most common diseases were coronary heart disease and type 2 diabetes mellitus. 2 groups were treated for a period of 12 months,with follow-up time from 6 to 10 months(average duration in 8 months). After treatment,the difference between plasma Hcy(Z=-7.63,P=0.000)and PWV(Z=-3.16,P=0.002)levels of the two groups were statistically significant. Conclusion Folic acid intervention can significantly reduce the level of plasma Hcy in patients with type H hypertension ,slow down the progression of atherosclerosis and reduce the risk factors of cardiovascular disease.关键词
H型高血压/叶酸/同型半胱氨酸/动脉硬化Key words
h-type hypertension/folic acid/homocysteine/arteriosclerosis引用本文复制引用
高霞,宋诗飞,谢伟,郭雪峰,高翔,张硕,古扎努尔,谢古月,金珂宇,杨一凡..叶酸干预H型高血压患者血浆同型半胱氨酸及动脉硬化的疗效[J].实用医学杂志,2017,33(16):2754-2756,3.基金项目
兵团科技攻关与成果转化计划项目(编号:2015AD008) （编号:2015AD008）
