实用医学杂志2017，Vol.33Issue(16)：2757-2760,4.DOI:10.3969/j.issn.1006-5725.2017.16.039
晚期胃癌卡培他滨或替吉奥维持治疗的临床研究
Clinical study of capecitabine or S-1 as maintenance treatment to patients with advanced gastric cancer
郑礼平 1张楠 1潘莹 1梁翠微 1龚五星1
作者信息
- 1. 519000 广东省珠海市人民医院(暨南大学附属珠海医院
- 折叠
摘要
Abstract
Objective To evaluate the efficacy and adverse effect caused by capecitabine compared with S-1 as maintenance treatment of patients with advanced gastric cancer (AGC). Methods A total of 123 AGC patients who did not suffer disease progression after first-line chemotherapy were randomized into three groups. The capecitabine group(Cap)received maintenance chemotherapy with capecitabine(1000 mg/m2 twice daily for 14 days,21 days/cycle),and the S-1 group(S1)received S-1(40,50,or 60 mg according to the body surface area and orally administered twice a day for 14 days ,21 days/cycle). The observation group was given the support-ive treatment. Patients kept this chemotherapy regimens until disease progressed or with intolerant toxicity. Re-sults The disease control rate was 70.7%in the Cap group and 80.5%in the S1 group(P=0.304). The median time of progression was 8.3 months in the Cap group and 8.5 months in the S1 group(P = 0.448). Maintenance chemotherapy groups showed better responses in the treatment group than the observation group ,which demonstrat-ed a median progression of 6.7 months(P<0.001). The median overall survival time was 15.3 months in the Cap group and 15.7 months in the S1 group(P = 0.637). Maintenance chemotherapy groups showed better responses than the observation group ,which demonstrated a median survival of 12.8 months (P < 0.05). The main side effects included hyperpigmentation,bone marrow suppression,nausea and vomiting and hand-foot syndrome. No death occurred in relation to the therapy. Conclusion The effectiveness of capecitabine and S-1 as maintenance chemotherapy in AGC patients after the first-line chemotherapy are similar,and both can prolong the time of overall survival. And the adverse reactions can be tolerated.关键词
晚期胃癌/卡培他滨/替吉奥/维持化疗Key words
advanced gastric cancer/capecitabine/S-1/maintenance chemotherapy引用本文复制引用
郑礼平,张楠,潘莹,梁翠微,龚五星..晚期胃癌卡培他滨或替吉奥维持治疗的临床研究[J].实用医学杂志,2017,33(16):2757-2760,4.
