生殖医学杂志2017，Vol.26Issue(8)：753-758,6.DOI:10.3969/j.issn.1004-3845.2017.08.004
卵巢正常反应人群拮抗剂方案中月经周期长短对卵泡发育同步化的影响
Influence of menstrual cycle length on follicle developmental synchronization in GnRH antagonist protocol in patients with normal ovarian response
摘要
Abstract
Objective: To investigate the influence of the length of menstrual cycle on follicle developmental synchronization in GnRH antagonist protocol in patients with normal ovarian response.Methods: The data of 236 infertile patients with normal ovarian response undergone IVF/ICSI-ET with GnRH antagonist protocol in Renmin Hospital of Wuhan University from January 2014 to November 2015 were retrospectively analyzed.The patients were divided into two groups according to the length of menstrual cycle:short menstrual cycle group(≤28 days,n=101) and long menstrual cycle group(≥29 day,n=135).The coefficient of variation of the follicular diameters on the initial day of using gonadotropin(Gn),Day 4,Day 7 after using Gn and HCG day,the clinical outcome were compared between the two groups.Results: The age,BMI,duration of gonadotropin(Gn) stimulation,estradiol level & endometrial thickness on HCG day,the coefficient of variation of the follicular diameters on the initial day of using Gn and Day 4 after using Gn,fertilization rate,cleavage rate,high qualified embryo rate,implantation rate,clinical pregnancy rate were not significantly different between two groups(P＞0.05).The antral follicle count[(14.98±4.24)vs.(11.72±4.29)],basal LH levels[(4.39±2.28)vs.(3.60±1.51)U/L],number of follicular diameters≥14 mm[(10.06±2.19)vs.(9.98±2.04)],number of oocytes retrieved[(11.81±4.32)vs.(9.65±4.33)] in the long menstrual cycle group were significantly higher than those in the short menstrual cycle group(P＜0.05).In contrast,basal FSH levels[(6.38±1.24)vs.(6.81±1.53)],the coefficient of variation of the follicular diameters on Day 7 after Gn stimulating[(0.122±0.045)vs.(0.143±0.055)] and HCG day[(0.208±0.037)vs.(0.218±0.041)],the total does of Gn used[(24.88±7.46) vs.(29.14±9.56)],progesterone levels on HCG day[(3.78±2.61) vs.(4.45±2.23)nmol/L] in the long menstrual cycle group were significantly lower than those in the short menstrual cycle group(P＜0.05).Conclusions: Among infertile female with normal ovarian response in GnRH antagonist protocol,the women with longer menstrual cycle may have better follicular developmental synchronization and obtained more retrieved oocytes.关键词
体外受精-胚胎移植/拮抗剂/月经周期/卵泡发育/同步性Key words
IVF-ET/GnRH antagonist/Menstrual cycle/Follicular development/Synchronism引用本文复制引用
高玥,王雅琴,徐望明,杨菁..卵巢正常反应人群拮抗剂方案中月经周期长短对卵泡发育同步化的影响[J].生殖医学杂志,2017,26(8):753-758,6.基金项目
国家自然科学基金青年科学基金项目(81501253) （81501253）
