生殖医学杂志2017，Vol.26Issue(8)：759-765,7.DOI:10.3969/j.issn.1004-3845.2017.08.005
35周岁以下女性移植不同等级及不同发育速度冻融囊胚的临床结局
Clinical outcome of frozen-thawed embryo transfer with blastocysts at different grades and development rates in women less than age 35 years
摘要
Abstract
Objective: To investigate the predictive value of development rate(Day 5 or Day 6) in the pregnancy outcomes of high-quality or poor-quality blastocyst transfer in frozen-thawed cycles for women less than age 35 years.Methods: The data of 1 539 frozen-thawed blastocyst transfer cycles of young women with age under 35 years were retrospectively analyzed.The cycles were divided into four groups according to the number and quality of blastocysts transferred:single high-quality(n=283) or double high-quality frozen-thawed blastocyst transfer(n=838),single poor-quality(n=194) or double poor-quality frozen-thawed blastocyst transfer(n=224).Each group was subdivided into Day 5 group and Day 6 group according to the time of blastocyst formation.The pregnancy outcomes were compared between the Day 5 and Day 6 frozen-thawed blastocysts among the four groups,respectively.Results: In single poor-quality frozen-thawed blastocyst(Day 5/Day 6) transfer cycles,the clinical pregnancy rate(46.88% vs.33.08%) and the implantation rate(46.88% vs.33.08%) in Day 5 group were higher than those in Day 6 group,but no significantly differences were observed(P＞0.05).In double poor-quality frozen-thawed blastocysts transfer cycles,the implantation rate(41.67% vs.31.01%) in Day 5 group was significantly higher than that in Day 6 group(P＜0.05).The clinic pregnancy rate(54.54% vs.47.47%) and the ongoing pregnancy rate(88.89% vs.76.00%) were higher and the early abortion rate(11.11% vs.22.67%)was lower in Day 5 group than Day 6 group,but no statistical significance were obtained(P＞0.05).In single high-quality frozen-thawed blastocyst transfer cycles,the clinical pregnancy rate(50.85% vs.52.83%),the implantation rate(51.41% vs.52.83%),the early abortion rate(18.89% vs.17.86%)and the ongoing pregnancy rate(80.00% vs.80.31%)were not significantly different between Day 5 group and Day 6 group(all P＞0.05).In double hight-quality frozen-thawed blastocysts transfer cycles,the clinical pregnancy rate(78.40% vs.74.86%),the implantation rate(61.48% vs.59.38%),the early abortion rate(7.90% vs.9.70%)and the ongoing pregnancy rate(91.52% vs.88.06%)were also not significantly different between Day 5 group and Day 6 group(all P＞0.05).Conclusions: The blastocyst development rate might have a role in predicting the embryo developing potential in poor-quality frozen-thawed blastocyst transfer cycles,while it might have no predictive value for the embryo developing potential of high-quality frozen-thawed blastocyst transfer in women less than age 35 years.Therefore,it might be considered a priority to take Day 5 poor-quality frozen-thawed blastocyst transfer in young patients if they have no high-quality frozen-thawed blastocysts.关键词
D5囊胚/D6囊胚/冻融胚胎移植/妊娠结局/囊胚质量Key words
Day 5/Day 6 blastocyst/Frozen-thawed cycles/Pregnancy rate/Blastocyst quality引用本文复制引用
谭巧,莫美兰,胡晓东,陈现,孙青,陈晓燕,曾勇..35周岁以下女性移植不同等级及不同发育速度冻融囊胚的临床结局[J].生殖医学杂志,2017,26(8):759-765,7.基金项目
深圳市科创委基础研究项目(JCYJ20160427113514229) （JCYJ20160427113514229）
