生殖医学杂志2017，Vol.26Issue(8)：766-771,6.DOI:10.3969/j.issn.1004-3845.2017.08.006
卵泡期高孕激素状态下促排卵方案在卵巢低反应患者中的应用
Clinical study of progestin-primed ovarian stimulation during follicular phase in patients with poor ovarian response
颜晓红 1陈琼华 1李仪 1孙金莉 1张妍 2王蔼明2
作者信息
- 1. 厦门大学附属第一医院生殖医学中心,厦门 361003
- 2. 海军总医院,北京 100048
- 折叠
摘要
Abstract
Objective: To investigate the effect of the follicular phase of the progestin-primed ovarian stimulation(PPOS) in poor ovarian responders(PORs) undergoing IVF.Methods: A prospective study was performed for 156 infertility patients with PORs undergoing IVF/ICSI.The patients were randomly divided into two groups:79 patients adopted PPOS protocol and 77 patients adopted antagonist protocol.The levels of FSH,LH,E2 and progesterone on trigger day were measured during ovarian stimulation in two groups.The following data including number of oocytes retrieved,number of mature oocytes,number of available embryos,average cost of gonadotropin used per cycle and subsequent pregnancy outcome of frozen-thawed(FET) cycles were compared between the two groups.Results: The levels of FSH,LH,E2,progesterone on trigger day in PPOS group were not significantly different with the antagonist group.The number of oocytes retrieved[(3.42±2.00) vs.(3.24±1.91)],number of mature oocytes[(2.91±2.03) vs.(2.69±1.81)],number of available embryos[(2.08±1.83) vs.(1.94±1.46)] in PPOS group were higher than the antagonist group,but there were no significant differences(P＞0.05).The average cost of gonadotropin used per cycle for PPOS group was significantly lower than that of antagonist group[(1 990±1 045) RMB vs.(3 925±745)RMB](P＜0.05).No significant differences were found in the clinical pregnancy rate(24.24% vs.22.86%),the implantation rate(15.38% vs.13.24%) and ongoing pregnancy rate(75.00% vs.62.50%)in subsequent frozen-thawed embryo transfer cycle between the two groups.The abortion rate was slightly higher with no significant difference in antagonist group(25.00% vs.37.50%)(P＞0.05).Conclusions: The progestin-primed ovarian stimulation in the follicular phase can effectively suppress the premature LH surge,and has no significant difference in the laboratory indications and clinical outcomes compared with the antagonist protocol in POR patients.However,it is more economical.The progestin-primed ovarian stimulation in follicular phase provides a new choice of ovarian stimulation scheme for PORs in clinical practice.关键词
卵泡期高孕激素状态下促排卵/卵巢低反应/冻融胚胎移植Key words
Progestin-primed ovarian stimulation/Poor ovarian response/Frozen-thawed embryo transfer引用本文复制引用
颜晓红,陈琼华,李仪,孙金莉,张妍,王蔼明..卵泡期高孕激素状态下促排卵方案在卵巢低反应患者中的应用[J].生殖医学杂志,2017,26(8):766-771,6.
