摘要
Abstract
Objective: To investigate the effect of hormone replacement treatment(HRT) with pretreatment of long-acting GnRH agonist(GnRH-a) on the clinical outcomes of frozen-thawed embryo transfer(FET) cycles in patients with polycystic ovarian syndrome(PCOS).Methods: The data of 152 FET cycles of PCOS patients were retrospectively analyzed in the Reproductive Center,Department of Gynecology & Obstetrics,Second Affiliated Hospital of Jilin University from June 2013 to June 2015.The patients were divided into group A with GnRH-a & HRT treatment(n=76) and group B only with HRT treatment(n=76).The age,duration of infertility,body mass index(BMI),basis LH,E2,T,fasting blood-glucose,fasting insulin,total cholesterol,triglyceride,number of frozen embryo implantation cycles,thickness of endometrium on FET day,embryo transfer rate,embryo implantation rate,clinical pregnancy rate,early abortion rate and ectopic pregnancy rate were compared between the two groups.Results: There was no significant differences in patients' age,duration of infertility,BMI,basis levels of LH,E2,T,fasting blood-glucose,fasting insulin,total cholesterol,triglyceride,cycle number,endometrial thickness on FET day,progesterone level and number of embryos transfer on progesterone conversion day(P＞0.05).However,the LH levels[(5.34±4.50) vs.(10.14±0.88)U/L],E2 levels[(145.26±57.50) vs.(179.71±89.89)pmol/L] and T levels[((2.15±0.45) vs.(2.53±0.28)nmol/L] were significantly lower than those in group B(P＜0.05).The embryo implantation rate(45.06% vs.32.20%) and clinical pregnancy rate(61.54% vs.42.11%) were significantly higher than those in group B(P＜0.05).Conclusions: Artificial HRT cycle for endometrial preparation after application of long-acting GnRHa for pituitary suppression can improve the outcome of FET for PCOS patients.关键词
冻融胚胎移植/多囊卵巢综合征/长效GnRH-a/人工周期Key words
Frozen-thawed embryo transfer/Polycystic ovarian syndrome/Long-acting GnRH-a/Artificial cycle
