生殖医学杂志2017，Vol.26Issue(8)：777-783,7.DOI:10.3969/j.issn.1004-3845.2017.08.008
联合促性腺激素/枸橼酸氯米芬的非降调节卵巢刺激方案在卵巢反应不良患者中的应用
Comparison of the efficacy of a modified non-down regulation ovarian stimulation protocol and standard long protocol in poor responder
李艳辉 1耿育红 1陈莉娟 1刘琳 1陈春艳 1高颖1
作者信息
- 1. 华中科技大学同济医学院附属协和医院妇产科,武汉 430022
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摘要
Abstract
Objective: To explore the efficacy of a modified and non-down regulation ovarian stimulation protocol(continuously co-treated with clomiphene citrate and gonadotropin) in the treatment of poor ovarian responder(POR) in accordance with Bologna criteria.Methods: A retrospective cohort study was conducted to collect the patients who underwent IVF/ICSI-ET treatment in our center from January 2012 to December 2014.Among the patients,191 patients with POR fulfilled the Bologna criteria and underwent IVF/ICSI-ET with standard long protocol(SLP group).The patients in SLP group were well-matched with POR patients undergone modified ovarian stimulation protocol(MOS group,n=382) at ratio 1:2 according to their age and basal antral follicle count.The pregnancy indicators and outcomes were compared between the two groups.Results: The number of retrieved oocytes and normal fertilized zygotes in MOS group were significantly more than those in the SLP group(P＜0.05).Although there was no significant difference in the cumulative clinical pregnancy rate per embryo transfer cycle between the two groups(55.34% vs.53.57%,P＞0.05),the cycle cancellation rate(15.18% vs.23.56%) and the abortion rate(8.77% vs.20.00%) in MOS group were significantly lower than those in the SLP group(P＜0.05).Thus a significantly higher cumulative live birth rate per initiated cycle was observed in MOS group than that in SLP group(38.74% vs.28.79%,P=0.02).Logistic regression analysis showed that the cumulative live birth rate was also significantly increased when the numbers of oocytes retrieved and transplantable embryos increased in the POR patients(P＜0.001).Conclusions: The modified ovarian simulation protocol can achieve better clinical outcomes compared with the standard long protocol.It can be used as a new promising approach for POR patients.关键词
卵巢反应不良/排卵诱导/体外受精/胚胎移植/累积活产率Key words
Poor ovarian response/Ovulation induction/In vitro fertilization/Embryo transfer/Cumulative live birth rate引用本文复制引用
李艳辉,耿育红,陈莉娟,刘琳,陈春艳,高颖..联合促性腺激素/枸橼酸氯米芬的非降调节卵巢刺激方案在卵巢反应不良患者中的应用[J].生殖医学杂志,2017,26(8):777-783,7.
