生殖医学杂志2017，Vol.26Issue(8)：784-790,7.DOI:10.3969/j.issn.1004-3845.2017.08.009
甲状腺自身抗体对体外受精-胚胎移植及冻融胚胎移植妊娠结局的影响
Influence of thyroid autoantibodies on pregnancy outcome in IVF-ET and frozen embryo transfer cycles
路鸿艳 1郝翠芳 2黄雨恢1
作者信息
- 1. 山东淄博市妇幼保健院生殖医学中心,淄博 255000
- 2. 山东烟台毓璜顶医院生殖医学科,烟台 264000
- 折叠
摘要
Abstract
Objective: To analyze the pregnancy outcome of IVF-ET and frozen embryo transfer(FET) in the patients with normal thyroid function and positive thyroid autoantibody.Methods: The data of 636 euthyroid patients undergone IVF-ET including 124 patients with positive thyroid autoantibody(ATA +) and 512 patients with negative thyroid autoantibody(ATA-) were retrospectively analyzed.Among them,423 patients underwent fresh embryo transfer including 74 patients of ATA+& 349 patients of ATA-,and 181 patients underwent FET including 31 patients of ATA +& 150 patients of ATA-.Results: In IVF-ET cycles,TSH and total days of Gn used in ATA +group were significantly higher than that of ATA-group,while high quality embryo rate in IVF & ICSI in ATA +group was significantly lower than that in ATA-group.In IVF-ET cycles,TG-Ab or TPO-Ab level was negatively correlated with fertilization rate(r=_0.30,P＜0.05 and r=_0.21,P＜0.05 respectively).In FET cycles,the early abortion rate of ATA +patients was significantly higher than that of ATA-patients(26.67% vs.1.47%,P＜0.05).Conclusions: Positive thyroid autoantibodies have a negative impact on pregnancy outcome,whether the patients are treated with IVF-ET or FET.关键词
体外受精-胚胎移植/冻融胚胎移植/甲状腺自身抗体/抗甲状腺球蛋白抗体/抗甲状腺过氧化物酶抗体/促甲状腺激素/早期流产率Key words
IVF-ET/Frozen embryo transfer/Anti-thyroid antibody/Thyroglobulin antibody/Thyroid peroxidase antibody/Thyroid stimulating hormone/Abortion rate引用本文复制引用
路鸿艳,郝翠芳,黄雨恢..甲状腺自身抗体对体外受精-胚胎移植及冻融胚胎移植妊娠结局的影响[J].生殖医学杂志,2017,26(8):784-790,7.
