生殖医学杂志2017，Vol.26Issue(8)：791-795,5.DOI:10.3969/j.issn.1004-3845.2017.08.010
高孕激素状态下促排卵与拮抗剂方案应用于卵巢低反应患者的促排卵疗效比较
Comparison of efficacy between progestin-primed ovarian stimulation and GnRH antagonist protocol in poor ovarian responders
摘要
Abstract
Objective: To compare the efficacy between progestin-primed ovarian stimulation(PPOS) and GnRH antagonist(GnRH-ant) protocol in poor ovarian responders undergone IVF.Methods: A retrospective analysis was performed in a total of 236 patients received artificial reproductive technology(ART) from October 2015 to October 2016.Among them,116 cycles were administered in progestin-primed ovarian stimulation protocol,while 120 cycles were adopted GnRH-ant protocol.The general conditions and the ovulation induction of the two groups were compared.Results: There were no significant differences in general condition and basic hormone levels between the two groups(P＞0.05).The amount of gonadotropin used[(2 729.25±1 048.5)U vs.(2 769.75±1 055.25) U],number of follicles with diameter≥14 mm on the HCG day[(3.51±2.44) vs.(3.95±2.77)],number of retrieved oocytes[(2.86±2.05) vs.(2.86±2.27)],cycle cancellation rate due to no available embryos(29.3% vs.30%) were not significantly different between the two groups(all P＞0.05).The 2PN fertilization rate(60.8% vs.58.6%),cleavage rate(83.5% vs.82.3%),high-quality embryo rate(54.0% vs.46.7%) and cycle cancellation rate(6.0% vs.5.8%) in PPOS group were slightly higher than those in GnRH-ant protocol group(P＞0.05).However,the rate of utilized embryos(72.2% vs.60.9%) in PPOS group was significantly higher than the GnRH-ant protocol group(P＜0.05).The duration of gonadotropin used[(11.11±4.09) vs.(9.73±2.68) days] and the occurrence of premature LH surge [0 vs.6.7%] were significantly different(P＜0.05).Conclusions: Progestin-primed ovarian stimulation protocol can effectively inhibit the premature LH surges and increase transplantable embryo rate,which can be served as an alternative and ideal treatment protocol for the poor ovarian responders.关键词
卵巢低反应/高孕激素状态下促排卵方案/拮抗剂方案/控制性促排卵Key words
Poor ovarian response/Progestin-primed ovarian stimulation protocol/GnRH-antagonist protocol/Controlled ovarian stimulation引用本文复制引用
杨菁,王艳丹,孙伟,冯亭亭,李洁..高孕激素状态下促排卵与拮抗剂方案应用于卵巢低反应患者的促排卵疗效比较[J].生殖医学杂志,2017,26(8):791-795,5.基金项目
国家自然科学基金(81571513) （81571513）
国家自然科学基金(81370767) （81370767）
