西北国防医学杂志2017，Vol.38Issue(7)：456-459,4.DOI:10.16021/j.cnki.1007-8622.2017.07.011
自体外周血干细胞移植治疗多发性骨髓瘤的临床疗效研究
Autologous peripheral blood stem cell transplantation in treatment of multiple myeloma
王存邦 1白海 1葸瑞 1潘耀柱 1吴涛 1徐淑芬 1张茜 1周进茂 1陈燕1
作者信息
- 1. 解放军兰州总医院血液科,甘肃兰州 730050
- 折叠
摘要
Abstract
Objective:To evaluate the therapeutic effect of autologous peripheral blood stem cell transplantation (APBSCT) for multiple myeloma (MM).Methods:Fourteen cases of patients who were diagnosed as MM received 4～6 courses of chemotherapy such as VTD and VD before transplantation.Peripheral blood stem cell were mobilized by chemotherapy combined G-CSF.Condition regimen were Bortezomib combined melphalan.Thalidomide was used as maintenance treatment after APBSCT.Results:①Nine cases of patients got complete remission(CR),3 cases got very good partial remission (VGPR) and 2 cases got partial remission(PR) before APBSCT.②All patients got rapidly hematopoietic reconstruction.The median time of ANC recovery≥0.5 × 109 /L were + 12 (+ 10-+ 15) days,platelet recovery≥20 ×109/L were +14(+13-+19) days.Blood marrow showed recovering in +21-+28 days.③Following up 4-105 months,3 cases of patients remissed in +5 to +17 months,and deathed lastly.1 case remissed in +46 months,received seckend APBSCT,and progress free of survival (PFS) were 105 months.Other 10 cases of patients were PFS.Conclusion:After courses of bortezomib-based chemotherapy,APBSCT and maintenance treatment with thalidomide were favorable methods to prolong PFS with MM patients.关键词
多发性骨髓瘤/自体造血干细胞移植/化疗/疗效Key words
multiple myeloma/autologous peripheral blood stem cell transplantation/chemotherapy/therapeutic effect分类
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王存邦,白海,葸瑞,潘耀柱,吴涛,徐淑芬,张茜,周进茂,陈燕..自体外周血干细胞移植治疗多发性骨髓瘤的临床疗效研究[J].西北国防医学杂志,2017,38(7):456-459,4.
