湖北医药学院学报2017，Vol.36Issue(3)：199-204,6.DOI:10.13819/j.issn.1006-9674.2017.03.002
血清高水平抵抗素作为乙型肝炎患者病情严重程度的指标
High Serum Resistin as an Index of Disease Severity for Patients with Chronic HBV Infection
摘要
Abstract
Objective To investigate the relationship between serum resistin levels and fibrosis severity in patients with HBV infection,and to explore the potential value of resistin as a marker of liver disease.Methods In this study,234 subjects with HBV infection were retrospectively selected,including 85 patients with chronic hepatitis B (CHB),70 patients with HBV-related liver cirrhosis (LC-B),and 79 patients with HBV-related liver failure (LF-B).Serum levels of resistin,IL -1,IL-6,IL-17,IL-23,TNF-α,and TGF-β1 were assayed by ELISA.Demographic and clinical characteristics of patients were extracted from clinical databases of Taihe Hospital,Hubei University of Medicine,including serum levels of alanine aminotransferase (ALT),aspartate aminotransferase (AST),total bilirubin (TBil),and liver stiffness (LS).Results All the selected patients with HBV infection showed significantly () levels of serum resistin,which was rarely detectable in the healthy controls.Serum resistin levels in patients with Crto,LC-B,and LF-B were (4.119±5.848) ng/ mL,(6.370±6.834) ng/mL,and (6.512±6.076) ng/mL,respectively.Compared with the CHB group,patients with LC -B or LF-B presented with significantly higher serum levels of resistin (P＜0.01).On the other hand,all of the enrolled patients had high serum levels of IL-1,IL-6,IL-17,TNF-α,and TGF-β1,but not IL-23.Interestingly,serum levels of resistin was significantly positively correlated with serum levels of TGF-β1 in LC-B patients (R =0.3090,P=0.0290),with IL-17 in LC-B (R=0.4022,P=0.0038) and LF-B patients (R=0.5466,P＜O.0001),and with AST (R=0.4501,P =0.0036) and LS (R =0.3415,P=0.0310) in CHB patients,respectively.Conclusions High levels of serum resistin are associated with intrahepatic inflammation and necrosis and may be used as a new indicator of disease severity for patients with chronic HBV infection.关键词
乙型肝炎/肝硬化/肝衰竭/抵抗素Key words
Hepatitis B/Liver cirrhosis/Liver failure/Proinflammatory cytokines/Resistin引用本文复制引用
张永红,魏志强,刘平,康健,柯昌征,汤守兵,陈悦,孟忠吉..血清高水平抵抗素作为乙型肝炎患者病情严重程度的指标[J].湖北医药学院学报,2017,36(3):199-204,6.基金项目
湖北省自然科学基金(2014CFB645) （2014CFB645）
湖北省科技计划研究与开发项目(2011BCB030) （2011BCB030）
湖北医药学院优秀中青年科技创新团队(2014CXG05) （2014CXG05）
太和医院联合精准医学科研项目(2016JZ05) （2016JZ05）
