中风与神经疾病杂志2017，Vol.34Issue(7)：628-632,5.
低血糖脑病患者外周血清S100β蛋白和神经元特异性烯醇化酶测定及意义
The determination and significance of S100 beta protein and neuron specific enolase in peripheral blood of patients with hypoglycemic encephalopathy
钟城垚 1陈乾 2周定群3
作者信息
- 1. 遵义市第一人民医院老年病科,贵州 遵义 563000
- 2. 遵义市第一人民医院神经内科,贵州 遵义 563000
- 3. 遵义市第一人民医院内分泌科,贵州 遵义 563000
- 折叠
摘要
Abstract
Objective To investigate the relationship between the levels of nerve biochemical markers of S100β protein and neuron specific enolase (NSE) in peripheral blood of patients with hypoglycemic encephalopathy (HE) and degree of neurological impairment.Methods 102 HE patients (study group) and 62 age and sex matched healthy volunteers (control group) were recruited in the present study.The general information and disease information of the subjects were collected.The expression of S100β protein and NSE was detected by enzyme-linked immunosorbent assay (ELISA).To analyze the influence of duration of hypoglycemia on the expression of S100β protein and NSE in serum of patients with HE.The National Institutes of Health Stroke Scale (NIHSS) was used to evaluate the neurological function of HE patients at three months after treatment.To analyze the correlation between the levels of serum S100β protein and NSE in patients with HE and the level of blood glucose,duration of hypoglycemia,NIHSS score,and to analyze the correlation between NIHSS score and blood glucose level and duration of hypoglycemia.Results The expression level of serum S100β protein and NSE in the study group was significantly higher than that in the normal control group (P< 0.01).With the prolonged duration of hypoglycemia,the expression of S100β protein and NSE in peripheral blood of patients with HE continued to rise to a peak of 24 hours (P<0.05).The expression level of S100β protein and NSE in serum of patients with HE was negatively correlated with blood glucose level (P<0.05),which was positively correlated with the duration of hypoglycemia (P<0.05),which was positively correlated with NIHSS score (P<0.05).NIHSS score was negatively correlated with blood glucose level (P<0.05),and was positively correlated with duration of hypoglycemia (P<0.05).Conclusion The expression of S100β protein and NSE in peripheral blood can reflect the degree of nerve function damage of HE patients to a certain extent,and has certain reference value for the diagnosis and prognosis of HE.关键词
低血糖脑病/S100β蛋白/神经元特异性烯醇化酶Key words
Hypoglycemic encephalopathy/S100β protein/Neuron specific enolase分类
临床医学引用本文复制引用
钟城垚,陈乾,周定群..低血糖脑病患者外周血清S100β蛋白和神经元特异性烯醇化酶测定及意义[J].中风与神经疾病杂志,2017,34(7):628-632,5.
