中国动脉硬化杂志2017，Vol.25Issue(8)：796-799,4.
心痛泰通过降低Lp-PLA2、IL-6、hs-CRP、LOX-1水平减轻兔动脉粥样硬化炎症反应
Xin Tong-tai reduces inflammation of atherosclerosis by lowering the levels of Lp-PLA2, IL-6, hs-CRP and LOX-1 in rabbits
摘要
Abstract
Aim To study the effects of Xin Tong-tai (XTT) on serum lipoprotein-associated phospholipase A2 (Lp-PLA2) and interleukin 6 (IL-6),and aortic tissue high-sensitivity C-reactive protein (hs-CRP) and lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) in atherosclerotic rabbits.Methods A total of 120 healthy Japanese rabbits were randomly divided into control group,model group,low-dose XTT group,middle-dose XTT group,high-dose XTT group and rosuvastatin group.In this prospective study,the drug intervention groups were treated with the corresponding drags at the same time.After 60 days,serum levels of Lp-PLA2 and IL-6 were measured;The contents of hsCRP and LOX-1 in thoracic aorta were detected by immunohistochemistry method.Results The serum levels of LpPLA2 and IL-6 in low-dose XTT group,middle-dose XTT group and high-dose XTT group were lower than those in model group (P＜0.01).Compared with low-dose XTT group,the serum levels of Lp-PLA2 and IL-6 were decreased in middledose XTT group,high-dose XTT group and rosuvastatin group (P＜0.01 or P＜0.05).The expression levels of hs-CRP and LOX-1 in middle-dose XTT group and high-dose XTT group were lower than those in model group (P＜0.01).Compared with low-dose XTT group,the expression levels of hs-CRP and LOX-1 were decreased in middle-dose XTT group,highdose XTT group and rosuvastatin group (P＜0.05).Immunohistochemical staining showed that in model group,there was a large amount of hs-CRP and LOX-1 expression in aortic intima;Compared with model group,the expressions of hs-CRP and LOX-1 in the aorta were reduced in low-dose XTT group,middle-dose XTT group,high-dose XTT group and rosuvastatin group.Conclusion Xin Tong-tai can decrease the levels of Lp-PLA2,IL-6,hs-CRP and LOX-1 in atherosclerotic rabbits,so as to achieve the effect of reducing atherosclerosis inflammatory reaction.关键词
心痛泰/动脉粥样硬化/脂蛋白相关磷脂酶A2/白细胞介素6/高敏C反应蛋白/血凝素样氧化型低密度脂蛋白受体1/兔Key words
Xin Tong-tai/Atherosclerosis/Lipoprotein-associated phospholipase A2/Interleukin-6/High-sensitivity C-reactive protein/Lectin-like oxidized low density lipoprotein receptor-1/Rabbit分类
医药卫生引用本文复制引用
易琼,李雅,郭志华,乐金海,任欣,申思..心痛泰通过降低Lp-PLA2、IL-6、hs-CRP、LOX-1水平减轻兔动脉粥样硬化炎症反应[J].中国动脉硬化杂志,2017,25(8):796-799,4.基金项目
湖南省中医药科研项目(201516) （201516）
