中国动脉硬化杂志2017，Vol.25Issue(8)：823-829,7.
绝经前后女性冠心病患者HDL及LDL颗粒与冠状动脉病变程度的相关性研究
Correlation between HDL, LDL particles and coronary artery lesions in premenopausal and postmenopausal female patients with coronary artery disease
尔璐 1侯曜曜 1张永亮 1宋晓苏 2白瑞 2张娜娜 3梁斌 2边云飞 2肖传实4
作者信息
- 1. 山西医科大学,山西省太原市030001
- 2. 山西医科大学第二医院心内科心血管疾病诊治及临床药理山西省重点实验室,山西省太原市030001
- 3. 山西医科大学第一医院特需病房,山西省太原市030001
- 4. 山西医科大学第一医院心内科,山西省太原市030001
- 折叠
摘要
Abstract
Aim To explore the relationship between high density lipoprotein (HDL) particle,low density lipoprotein (LDL) particle and coronary artery lesions in premenopausal and postmenopansal female patients with coronary artery disease.Methods Data were collected from 79 female patients with coronary artery disease diagnosed by coronary angiography.According to whether menopause,the patients were divided into premenopausal group (n =37) and postmenopausal group (n =42).HDL particles and LDL particles were detected and analyzed by Lipoprint lipoprotein analyzer.The relationship between two lipoprotein particles and severity of coronary artery lesions was studied.Results Compared with the premenopausal group,large particle HDL concentration (102.6±45.2 mg/L vs 143.8±49.7 mg/L,P＜0.05)and its proportion (23.34％±8.26％ vs 31.15％±7.98％,P＜0.05),and mean diameter of LDL particles (259.5±8.1(A) vs 265.7±3.7(A)t,P＜0.05) were decreased,small particle HDL concentration (124.0±76.8 mg/L vs 87.0±34.9 mg/L,P＜ 0.05) and its proportion (27.26％±12.34％ vs 18.62％±6.53％,P＜0.05),B type proportion in LDL (73.8％ vs 48.6％,P＜0.05),and Gensini score (50.88±26.46 vs 30.43±18.54,P＜0.05) were increased,in the postmenopausal group.In premenopausal group and postmenopausal group,large particle HDL concentration and the average diameter of LDL particles in patients with multivessel lesions were lower than those in patients with single vessel lesions,and the Gensini score was higher than that in patients with single vessel lesions.Large particle HDL concentration and the average diameter of LDL particles in postmenopausal group were lower than those in premenopausal group,and small particle HDL proportion and Gensini score in postmenopausal group were higher than those in premenopausal group.LDL particle size and large particle HDL concentration were negatively correlated with the Gensini score in the premenopausal group and the postmenopausal group.Conclusion Compared with the premenopausal group,large particle HDL concentration is lower,small particle HDL concentration is higher,the average diameter of LDL particle is smaller,and the degree of coronary artery lesions is more serious in the postmenopausal group.Large particle HDL concentration and the mean diameter of LDL are significantly correlated with the severity of coronary artery lesions.关键词
绝经前/绝经后/冠心病/高密度脂蛋白颗粒/低密度脂蛋白颗粒/冠状动脉病变程度Key words
Premenopausal/Postmenopausal/Coronary artery disease/High density lipoprotein particle/Low density lipoprotein particle/Coronary artery lesion分类
医药卫生引用本文复制引用
尔璐,侯曜曜,张永亮,宋晓苏,白瑞,张娜娜,梁斌,边云飞,肖传实..绝经前后女性冠心病患者HDL及LDL颗粒与冠状动脉病变程度的相关性研究[J].中国动脉硬化杂志,2017,25(8):823-829,7.
